Sideritis Perfoliata (Subsp. Perfoliata) nutritive value and its potential medicinal properties

dc.contributor.authorLall, Namrita
dc.contributor.authorChrysargyris, Antonios
dc.contributor.authorLambrechts, Isa Anina
dc.contributor.authorFibrich, Bianca
dc.contributor.authorBlom van Staden, Analike
dc.contributor.authorTwilley, Danielle
dc.contributor.authorDe Canha, Marco Nuno
dc.contributor.authorOosthuizen, Carel Basson
dc.contributor.authorBodiba, Dikonketso
dc.contributor.authorTzortzakis, Nikolaos
dc.contributor.emailnamrita.lall@up.ac.zaen_ZA
dc.date.accessioned2020-03-30T14:09:11Z
dc.date.available2020-03-30T14:09:11Z
dc.date.issued2019-10-30
dc.description.abstractSideritis perfoliata L. subsp. perfoliata is an endemic species of the Eastern Mediterranean region with several uses in traditional medicine. The present study aims to explore the unknown properties of S. perfoliata investigating the nutritional content as well as the antioxidant, anticancer, antituberculosis, antiwrinkle, anti-acne, hyper/hypo-pigmentation and antibacterial activities. Mineral content, nutritional value, the composition and antioxidant properties of the essential oil, the antityrosinase, the antibacterial activity and anti-elastase potential of the extract, were evaluated. The antiproliferative activity of S. perfoliata against cervical cancer (HeLa), human melanoma (UCT-Mel-1), human hepatocellular carcinoma (HepG2) and human epidermoid carcinoma (A431) was investigated. Cytotoxic e ects on normal human keratinocyte (HaCat) and kidney epithelial (Vero) cell lines were also determined. Sideritis perfoliata exhibited high nutritional value of proteins and minerals (K, P, Mg, Fe, Zn, Cu). The most abundant components of the essential oil were found to be -pinene, -phelladrene, valeranone, -pinene and sabinene. The ethanolic extract of S. perfoliata displayed moderate antioxidant potential and antibacterial activity against Prevotella intermedia. Noteworthy elastase and moderate anticancer potential against the human liver cancer cell line (HepG2) was observed with IC50 values of 57.18 3.22 g/mL and 64.27 2.04 g/mL respectively. The noteworthy in vitro activity of S. perfoliata could be due to the presence of flavonoids and phenols in the leaves, having high nutritional value. Sideritis perfoliata could potentially be useful to reduce the appearance of wrinkles and for the treatment of liver cancer. The moderate antibacterial, antioxidant and elastase activity of the plant can be linked to the traditional use of S. perfoliata for the treatment of wounds and inflammation.en_ZA
dc.description.departmentPlant Production and Soil Scienceen_ZA
dc.description.librarianam2020en_ZA
dc.description.sponsorshipThe National Research Foundation (NRF) and the University of Pretoria. Funding for publication was granted by the Cyprus University of Technology Open Access Author Fund.en_ZA
dc.description.urihttps://www.mdpi.com/journal/antioxidantsen_ZA
dc.identifier.citationLall, N., Chrysargyris, A., Lambrechts, I. et al. 2019, 'Sideritis Perfoliata (Subsp. Perfoliata) nutritive value and its potential medicinal properties', Antioxidants, vol. 8, no. 11, art. 521, pp. 1-18.en_ZA
dc.identifier.issn2076-3921 (online)
dc.identifier.other10.3390/antiox8110521
dc.identifier.urihttp://hdl.handle.net/2263/73875
dc.language.isoenen_ZA
dc.publisherMDPIen_ZA
dc.rights© 2019 by the authors. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license.en_ZA
dc.subjectSideritis perfoliataen_ZA
dc.subjectWrinklesen_ZA
dc.subjectCutibacterium acnesen_ZA
dc.subjectAntimycobacterialen_ZA
dc.subjectMelanin inhibitionen_ZA
dc.subjectAntioxidant capacityen_ZA
dc.titleSideritis Perfoliata (Subsp. Perfoliata) nutritive value and its potential medicinal propertiesen_ZA
dc.typeArticleen_ZA

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