Adult neurogenesis and its anatomical context in the hippocampus of three mole-rat species
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Date
Authors
Amrein, Irmgard
Becker, Anton S.
Engler, Stefanie
Huang, Shih-hui
Müller, Julian
Slomianka, Lutz
Oosthuizen, Maria Kathleen
Journal Title
Journal ISSN
Volume Title
Publisher
Frontiers Research Foundation
Abstract
African mole-rats (family Bathyergidae) are small to medium sized, long-lived, and strictly subterranean
rodents that became valuable animal models as a result of their longevity and diversity in social
organization. The formation and integration of new hippocampal neurons in adult mammals (adult
hippocampal neurogenesis, AHN) correlates negatively with age and positively with habitat complexity. Here
we present quantitative data on AHN in wild-derived mole-rats of 1 year and older, and briefly describe its
anatomical context including markers of neuronal function (calbindin and parvalbumin). Solitary Cape molerats
(Georychus capensis), social highveld mole-rats (Cryptomys hottentotus pretoriae), and eusocial naked
mole-rats (Heterocephalus glaber) were assessed. Compared to other rodents, the hippocampal formation
in mole-rats is small, but shows a distinct cytoarchitecture in the dentate gyrus and CA1. Distributions of
the calcium-binding proteins differ from those seen in rodents; e.g., calbindin in CA3 of naked mole-rats
distributes similar to the pattern seen in early primate development, and calbindin staining extends into the
stratum lacunosum-moleculare of Cape mole-rats. Proliferating cells and young neurons are found in low
numbers in the hippocampus of all three mole-rat species. Resident granule cell numbers are low as well.
Proliferating cells expressed as a percentage of resident granule cells are in the range of other rodents,
while the percentage of young neurons is lower than that observed in surface dwelling rodents. Between
mole-rat species, we observed no difference in the percentage of proliferating cells. The percentages of
young neurons are high in social highveld and naked mole-rats, and low in solitary Cape mole-rats. The
findings support that proliferation is regulated independently of average life expectancy and habitat.
Instead, neuronal differentiation reflects species-specific demands, which appear lower in subterranean
rodents.
Description
Keywords
Bathyergidae, Calcium-binding proteins, Cape mole-rat (Georychus capensis), Comparative neuroanatomy, Highveld mole-rat (Cryptomys hottentotus pretoriae), Neurogenesis, Stereology, African mole-rats (Bathyergidae), Naked mole-rat (Heterocephalus glaber)
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Citation
Amrein, I, Becker, AS, Engler, S, Huang, S-H, Müller, J, Slomianka, L, & Oosthuizen, MK 2014, 'Adult neurogenesis and its anatomical context in the hippocampus of three mole-rat species', Frontiers in Neuroanatomy, vol. 8, no. 5, #39, pp. 1-11.