SAG-2 oral rabies vaccine
| dc.contributor.author | Schumacher, C.L. | |
| dc.contributor.author | Coulon, Patrice | |
| dc.contributor.author | Lafay, F. | |
| dc.contributor.author | Benejean, J. | |
| dc.contributor.author | Aubert, M.F.A. | |
| dc.contributor.author | Barrat, J. | |
| dc.contributor.author | Aubert, A. | |
| dc.contributor.author | Flamand, Anne | |
| dc.contributor.author | Rabies in Southern and Eastern Africa. Workshop. (1993, Pretoria, South Africa) | |
| dc.contributor.editor | Verwoerd, Daniel Wynand | |
| dc.date.accessioned | 2014-08-15T08:18:48Z | |
| dc.date.available | 2014-08-15T08:18:48Z | |
| dc.date.created | 2013 | |
| dc.date.issued | 1993 | |
| dc.description | The articles have been scanned in colour with a HP Scanjet 5590; 600dpi. Adobe Acrobat XI Pro was used to OCR the text and also for the merging and conversion to the final presentation PDF-format. | en |
| dc.description.abstract | The live modified rabies virus vaccine strain SAG-2 was selected from SAD Berne in a two step process employing anti-rabies glycoprotein monoclonal antibodies. The first two nucleotides coding for the amino acid in position 333 of the rabies glycoprotein are mutated. Arginine at position 333, which is associated with rabies pathogenicity, was substituted first by lysine and then by glutamic acid. The two nucleotide differences at position 333 in SAG-2 to any of six possible arginine triplets translated into excellent genetic stability and apathogenicity for adult mice, foxes, cats and dogs. The vaccination of foxes and dogs by the oral route provided protection against a lethal challenge with rabies virus. | en |
| dc.description.librarian | mn2014 | |
| dc.identifier.citation | Schumacher, CL, Coulon, P, Lafay, F, Benejean, J, Aubert, MFA, Barrat, J, Aubert, A & Flamand, A 1993, 'SAG-2 oral rabies vaccine’, Onderstepoort Journal of Veterinary Research, vol. 60, no. 4, pp. 459-462. | en |
| dc.identifier.issn | 0330-2465 | |
| dc.identifier.uri | http://hdl.handle.net/2263/41330 | |
| dc.language.iso | en | en |
| dc.publisher | Published by the Agricultural Research Council, Onderstepoort Veterinary Institute | en |
| dc.rights | © ARC-Onderstepoort (original). © University of Pretoria. Dept of Library Services (digital). | en |
| dc.subject | Veterinary medicine | en |
| dc.subject | Rabies in southern and eastern Africa. Proceedings of a workshop held at the Faculty of Veterinary Science, University of Pretoria, Onderstepoort, South Africa, 3-5 May 1993 | en |
| dc.subject.lcsh | Veterinary medicine -- South Africa | |
| dc.subject.lcsh | Rabies in animals | en |
| dc.title | SAG-2 oral rabies vaccine | en |
| dc.type | Article | en |