Disentangling the role of Africa in the global spread of H5 highly pathogenic avian influenza

dc.contributor.authorFusaro, Alice
dc.contributor.authorZecchin, Bianca
dc.contributor.authorVrancken, Bram
dc.contributor.authorAbolnik, Celia
dc.contributor.authorAdemun, Rose
dc.contributor.authorAlassane, Abdou
dc.contributor.authorArafa, Abdelsatar
dc.contributor.authorAwuni, Joseph Adongo
dc.contributor.authorCouacy-Hymann, Emmanuel
dc.contributor.authorCoulibaly, M.’ Betiegue
dc.contributor.authorGaidet, Nicolas
dc.contributor.authorGo-Mar, Emilie
dc.contributor.authorJoannis, Tony
dc.contributor.authorJumbo, Simon Dickmu
dc.contributor.authorMinoungou, Germaine
dc.contributor.authorMeseko, Clement
dc.contributor.authorSouley, Maman Moutari
dc.contributor.authorNdumu, Deo Birungi
dc.contributor.authorShittu, Ismaila
dc.contributor.authorTwabela, Augustin
dc.contributor.authorWade, Abel
dc.contributor.authorWiersma, Lidewij
dc.contributor.authorAkpeli, Yao P.
dc.contributor.authorZamperin, Gianpiero
dc.contributor.authorMilani, Adelaide
dc.contributor.authorLemey, Philippe
dc.contributor.authorMonne, Isabella
dc.date.accessioned2020-02-28T13:52:57Z
dc.date.available2020-02-28T13:52:57Z
dc.date.issued2019-11-22
dc.description.abstractThe role of Africa in the dynamics of the global spread of a zoonotic and economicallyimportant virus, such as the highly pathogenic avian influenza (HPAI) H5Nx of the Gs/GD lineage, remains unexplored. Here we characterise the spatiotemporal patterns of virus diffusion during three HPAI H5Nx intercontinental epidemic waves and demonstrate that Africa mainly acted as an ecological sink of the HPAI H5Nx viruses. A joint analysis of host dynamics and continuous spatial diffusion indicates that poultry trade as well as wild bird migrations have contributed to the virus spreading into Africa, with West Africa acting as a crucial hotspot for virus introduction and dissemination into the continent. We demonstrate varying paths of avian influenza incursions into Africa as well as virus spread within Africa over time, which reveal that virus expansion is a complex phenomenon, shaped by an intricate interplay between avian host ecology, virus characteristics and environmental variables.en_ZA
dc.description.departmentMicrobiology and Plant Pathologyen_ZA
dc.description.librarianam2020en_ZA
dc.description.sponsorshipUSAID under the OSRO/GLO/501/USA and OSRO/GLO/507/USA projects and by European Union’s Horizon 2020 research and innovation programme under grant agreement No 727922 (DELTAFLU). The European Research Council under the European Unionʼs Horizon 2020 research and innovation programme (grant agreement no. 725422-ReservoirDOCS). P.L. acknowledges support by the Research Foundation – Flanders FWO, G066215N, G0D5117N and G0B9317N). B.V. is a postdoctoral research fellow supported by the FWO.en_ZA
dc.description.urihttp://www.nature.com/naturecommunicationsen_ZA
dc.identifier.citationFusaro, A., Zecchin, B., Vrancken, B. et al. 2019, 'Disentangling the role of Africa in the global spread of H5 highly pathogenic avian influenza', Nature Communications, vol. 10, art. 5310, pp. 1-13.en_ZA
dc.identifier.issn2041-1723 (online)
dc.identifier.other10.1038/s41467-019-13287-y
dc.identifier.urihttp://hdl.handle.net/2263/73614
dc.language.isoenen_ZA
dc.publisherNature Publishing Groupen_ZA
dc.rights© The Author(s) 2019en_ZA
dc.subjectVirus diffusionen_ZA
dc.subjectIntercontinental epidemic wavesen_ZA
dc.subjectAvian influenza virus (AIV)en_ZA
dc.subjectAfricaen_ZA
dc.titleDisentangling the role of Africa in the global spread of H5 highly pathogenic avian influenzaen_ZA
dc.typeArticleen_ZA

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