Transcriptome-wide association study of breast cancer risk by estrogen-receptor status
dc.contributor.author | Feng, Helian | |
dc.contributor.author | Gusev, Alexander | |
dc.contributor.author | Pasaniuc, Bogdan | |
dc.contributor.author | Wu, Lang | |
dc.contributor.author | Long, Jirong | |
dc.contributor.author | Abu-full, Zomoroda | |
dc.contributor.author | Aittomäki, Kristiina | |
dc.contributor.author | Andrulis, Irene L. | |
dc.contributor.author | Anton-Culver, Hoda | |
dc.contributor.author | Antoniou, Antonis C. | |
dc.contributor.author | Arason, Adalgeir | |
dc.contributor.author | Arndt, Volker | |
dc.contributor.author | Aronson, Kristan J. | |
dc.contributor.author | Arun, Banu K. | |
dc.contributor.author | Asseryanis, Ella | |
dc.contributor.author | Auer, Paul L. | |
dc.contributor.author | Azzollini, Jacopo | |
dc.contributor.author | Balmana, Judith | |
dc.contributor.author | Barkardottir, Rosa B. | |
dc.contributor.author | Barnes, Daniel R. | |
dc.contributor.author | Barrowdale, Daniel | |
dc.contributor.author | Beckmann, Matthias W. | |
dc.contributor.author | Behrens, Sabine | |
dc.contributor.author | Benitez, Javier | |
dc.contributor.author | Bermisheva, Marina | |
dc.contributor.author | Białkowska, Katarzyna | |
dc.contributor.author | Blanco, Ana | |
dc.contributor.author | Blomqvist, Carl | |
dc.contributor.author | Boeckx, Bram | |
dc.contributor.author | Bogdanova, Natalia V. | |
dc.contributor.author | Bojesen, Stig E. | |
dc.contributor.author | Bolla, Manjeet K. | |
dc.contributor.author | Bonanni, Bernardo | |
dc.contributor.author | Borg, Ake | |
dc.contributor.author | Brauch, Hiltrud | |
dc.contributor.author | Brenner, Hermann | |
dc.contributor.author | Briceno, Ignacio | |
dc.contributor.author | Broeks, Annegien | |
dc.contributor.author | Bruning, Thomas | |
dc.contributor.author | Burwinkel, Barbara | |
dc.contributor.author | Cai, Qiuyin | |
dc.contributor.author | Caldés, Trinidad. | |
dc.contributor.author | Caligo, Maria A. | |
dc.contributor.author | Campbell, Ian | |
dc.contributor.author | Canisius, Sander | |
dc.contributor.author | Campa, Daniele | |
dc.contributor.author | Carter, Brian D. | |
dc.contributor.author | Carter, Jonathan | |
dc.contributor.author | Castelao, Jose E. | |
dc.contributor.author | Chang-Claude, Jenny | |
dc.contributor.author | Chanock, Stephen J. | |
dc.contributor.author | Christiansen, Hans | |
dc.contributor.author | Chung, Wendy K. | |
dc.contributor.author | Claes, Kathleen B.M. | |
dc.contributor.author | Clarke, Christine L. | |
dc.contributor.author | Couch, Fergus J. | |
dc.contributor.author | Cox, Angela | |
dc.contributor.author | Cross, Simon S. | |
dc.contributor.author | Cybulski, Cezary | |
dc.contributor.author | Czene, Kamila | |
dc.contributor.author | Daly, Mary B. | |
dc.contributor.author | De la Hoya, Miguel | |
dc.contributor.author | De Leeneer, Kim | |
dc.contributor.author | Dennis, Joe | |
dc.contributor.author | Devilee, Peter | |
dc.contributor.author | Diez, Orland | |
dc.contributor.author | Domchek, Susan M. | |
dc.contributor.author | Dork, Thilo | |
dc.contributor.author | Dos-Santos-Silva, Isabel | |
dc.contributor.author | Dunning, Alison M. | |
dc.contributor.author | Dwek, Miriam | |
dc.contributor.author | Eccles, Diana M. | |
dc.contributor.author | Ejlertsen, Bent | |
dc.contributor.author | Ellberg, Carolina | |
dc.contributor.author | Engel, Christoph | |
dc.contributor.author | Eriksson, Mikael | |
dc.contributor.author | Fasching, Peter A. | |
dc.contributor.author | Fletcher, Olivia | |
dc.contributor.author | Flyger, Henrik | |
dc.contributor.author | Fostira, Florentia | |
dc.contributor.author | Friedman, Eitan | |
dc.contributor.author | Fritschi, Lin | |
dc.contributor.author | Frost, Debra | |
dc.contributor.author | Gabrielson, Marike | |
dc.contributor.author | Ganz, Patricia A. | |
dc.contributor.author | Gapstur, Susan M. | |
dc.contributor.author | Garber, Judy | |
dc.contributor.author | Garcia-Closas, Montserrat | |
dc.contributor.author | Garcia-Saenz, Jose A. | |
dc.contributor.author | Gaudet, Mia M. | |
dc.contributor.author | Giles, Graham G. | |
dc.contributor.author | Glendon, Gord | |
dc.contributor.author | Godwin, Andrew K. | |
dc.contributor.author | Goldberg, Mark S. | |
dc.contributor.author | Goldgar, David E. | |
dc.contributor.author | Gonzalez-Neira, Anna | |
dc.contributor.author | Greene, Mark H. | |
dc.contributor.author | Gronwald, Jacek | |
dc.contributor.author | Guénel, Pascal | |
dc.contributor.author | Haiman, Christopher A. | |
dc.contributor.author | Hall, Per | |
dc.contributor.author | Hamann, Ute | |
dc.contributor.author | Hake, Christopher | |
dc.contributor.author | He, Wei | |
dc.contributor.author | Heyworth, Jane | |
dc.contributor.author | Hogervorst, Frans B.L. | |
dc.contributor.author | Hollestelle, Antoinette | |
dc.contributor.author | Hooning, Maartje J. | |
dc.contributor.author | Hoover, Robert N. | |
dc.contributor.author | Hopper, John L. | |
dc.contributor.author | Huang, Guanmengqian | |
dc.contributor.author | Humphreys, Keith | |
dc.contributor.author | Imyanitov, Evgeny N. | |
dc.contributor.author | Isaacs, Claudine | |
dc.contributor.author | Jakimovska, Milena | |
dc.contributor.author | Jakubowska, Anna | |
dc.contributor.author | James, Paul | |
dc.contributor.author | Janavicius, Ramunas | |
dc.contributor.author | Jankowitz, Rachel C. | |
dc.contributor.author | John, Esther M. | |
dc.contributor.author | Johnson, Nichola | |
dc.contributor.author | Joseph, Vijai | |
dc.contributor.author | Jung, Audrey | |
dc.contributor.author | Karlan, Beth Y. | |
dc.contributor.author | Khusnutdinova, Elza | |
dc.contributor.author | Kiiski, Johanna I. | |
dc.contributor.author | Konstantopoulou, Irene | |
dc.contributor.author | Kristensen, Vessela | |
dc.contributor.author | Laitman, Yael | |
dc.contributor.author | Lambrechts, Diether | |
dc.contributor.author | Lazaro, Conxi | |
dc.contributor.author | Leroux, Dominique | |
dc.contributor.author | Leslie, Goska | |
dc.contributor.author | Lester, Jenny | |
dc.contributor.author | Lesueur, Fabienne | |
dc.contributor.author | Lindor, Noralane | |
dc.contributor.author | Lindstrom, Sara | |
dc.contributor.author | Lo, Wing-Yee | |
dc.contributor.author | Loud, Jennifer T. | |
dc.contributor.author | Lubinski, Jan | |
dc.contributor.author | Makalic, Enes | |
dc.contributor.author | Mannermaa, Arto | |
dc.contributor.author | Manoochehri, Mehdi | |
dc.contributor.author | Manoukian, Siranoush | |
dc.contributor.author | Margolin, Sara | |
dc.contributor.author | Martens, John W.M. | |
dc.contributor.author | Martinez, Maria E. | |
dc.contributor.author | Matricardi, Laura | |
dc.contributor.author | Maurer, Tabea | |
dc.contributor.author | Mavroudis, Dimitrios | |
dc.contributor.author | McGuffog, Lesley | |
dc.contributor.author | Meindl, Alfons | |
dc.contributor.author | Menon, Usha | |
dc.contributor.author | Michailidou, Kyriaki | |
dc.contributor.author | Kapoor, Pooja M. | |
dc.contributor.author | Miller, Austin | |
dc.contributor.author | Montagna, Marco | |
dc.contributor.author | Moreno, Fernando | |
dc.contributor.author | Moserle, Lidia | |
dc.contributor.author | Mulligan, Anna M. | |
dc.contributor.author | Muranen, Taru A. | |
dc.contributor.author | Nathanson, Katherine L. | |
dc.contributor.author | Neuhausen, Susan L. | |
dc.contributor.author | Nevanlinna, Heli | |
dc.contributor.author | Nevelsteen, Ines | |
dc.contributor.author | Nielsen, Finn C. | |
dc.contributor.author | Nikitina-Zake, Liene | |
dc.contributor.author | Offit, Kenneth | |
dc.contributor.author | Olah, Edith | |
dc.contributor.author | Olopade, Olufunmilayo I. | |
dc.contributor.author | Olsson, Hakan | |
dc.contributor.author | Osorio, Ana | |
dc.contributor.author | Papp, Janos | |
dc.contributor.author | Park-Simon, Tjoung-Won | |
dc.contributor.author | Parsons, Michael T. | |
dc.contributor.author | Pedersen, Inge S. | |
dc.contributor.author | Peixoto, Ana | |
dc.contributor.author | Peterlongo, Paolo | |
dc.contributor.author | Peto, Julian | |
dc.contributor.author | Pharoah, Paul D.P. | |
dc.contributor.author | Phillips, Kelly-Anne | |
dc.contributor.author | Plaseska-Karanfilska, Dijana | |
dc.contributor.author | Poppe, Bruce | |
dc.contributor.author | Pradhan, Nisha | |
dc.contributor.author | Prajzendanc, Karolina | |
dc.contributor.author | Presneau, Nadege | |
dc.contributor.author | Punie, Kevin | |
dc.contributor.author | Pylkäs, Katri | |
dc.contributor.author | Radice, Paolo | |
dc.contributor.author | Rantala, Johanna | |
dc.contributor.author | Rashid, Muhammad Usman | |
dc.contributor.author | Rennert, Gad | |
dc.contributor.author | Risch, Harvey A. | |
dc.contributor.author | Robson, Mark | |
dc.contributor.author | Romero, Atocha | |
dc.contributor.author | Saloustros, Emmanouil | |
dc.contributor.author | Sandler, Dale P. | |
dc.contributor.author | Santos, Catarina | |
dc.contributor.author | Sawyer, Elinor J. | |
dc.contributor.author | Schmidt, Marjanka K. | |
dc.contributor.author | Schmidt, Daniel F. | |
dc.contributor.author | Schmutzler, Rita K. | |
dc.contributor.author | Schoemaker, Minouk J. | |
dc.contributor.author | Scott, Rodney J. | |
dc.contributor.author | Sharma, Priyanka | |
dc.contributor.author | Shu, Xiao-Ou | |
dc.contributor.author | Simard, Jacques | |
dc.contributor.author | Singer, Christian F. | |
dc.contributor.author | Skytte, Anne-Bine | |
dc.contributor.author | Soucy, Penny | |
dc.contributor.author | Southey, Melissa C. | |
dc.contributor.author | Spinelli, John J. | |
dc.contributor.author | Spurdle, Amanda B. | |
dc.contributor.author | Stone, Jennifer | |
dc.contributor.author | Swerdlow, Anthony J. | |
dc.contributor.author | Tapper, William J. | |
dc.contributor.author | Taylor, Jack A. | |
dc.contributor.author | Teixeira, Manuel R. | |
dc.contributor.author | Terry, Mary Beth | |
dc.contributor.author | Teule, Alex | |
dc.contributor.author | Thomassen, Mads | |
dc.contributor.author | Thöne, Kathrin | |
dc.contributor.author | Thull, Darcy L. | |
dc.contributor.author | Tischkowitz, Marc | |
dc.contributor.author | Toland, Amanda E. | |
dc.contributor.author | Tollenaar, Rob A.E.M. | |
dc.contributor.author | Torres, Diana | |
dc.contributor.author | Truong, Therese | |
dc.contributor.author | Tung, Nadine | |
dc.contributor.author | Vachon, Celine M. | |
dc.contributor.author | Van den Ouweland, Ans M.W. | |
dc.contributor.author | Van Asperen, Christi J. | |
dc.contributor.author | Jansen van Rensburg, Elizabeth | |
dc.contributor.author | Vega, Ana | |
dc.contributor.author | Viel, Alessandra | |
dc.contributor.author | Vieiro-Balo, Paula | |
dc.contributor.author | Wang, Qin | |
dc.contributor.author | Wappenschmidt, Barbara | |
dc.contributor.author | Weinberg, Clarice R. | |
dc.contributor.author | Weitzel, Jeffrey N. | |
dc.contributor.author | Wendt, Camilla | |
dc.contributor.author | Winqvist, Robert | |
dc.contributor.author | Yang, Xiaohong R. | |
dc.contributor.author | Yannoukakos, Drakoulis | |
dc.contributor.author | Ziogas, Argyrios | |
dc.contributor.author | Milne, Roger L. | |
dc.contributor.author | Easton., Douglas F. | |
dc.contributor.author | Chenevix-Trench, Georgia | |
dc.contributor.author | Zheng, Wei | |
dc.contributor.author | Kraft, Peter | |
dc.contributor.author | Jiang, Xia | |
dc.date.accessioned | 2021-06-02T07:42:32Z | |
dc.date.available | 2021-06-02T07:42:32Z | |
dc.date.issued | 2020-07 | |
dc.description.abstract | Previous transcriptome-wide association studies (TWAS) have identified breast cancer risk genes by integrating data from expression quantitative loci and genome-wide association studies (GWAS), but analyses of breast cancer subtype-specific associations have been limited. In this study, we conducted a TWAS using gene expression data from GTEx and summary statistics from the hitherto largest GWAS meta-analysis conducted for breast cancer overall, and by estrogen receptor subtypes (ER+ and ER−). We further compared associations with ER+ and ER− subtypes, using a case-only TWAS approach. We also conducted multigene conditional analyses in regions with multiple TWAS associations. Two genes, STXBP4 and HIST2H2BA, were specifically associated with ER+ but not with ER− breast cancer. We further identified 30 TWAS-significant genes associated with overall breast cancer risk, including four that were not identified in previous studies. Conditional analyses identified single independent breast-cancer gene in three of six regions harboring multiple TWAS-significant genes. Our study provides new information on breast cancer genetics and biology, particularly about genomic differences between ER+ and ER− breast cancer. | en_ZA |
dc.description.department | Genetics | en_ZA |
dc.description.librarian | pm2021 | en_ZA |
dc.description.uri | https://onlinelibrary.wiley.com/journal/10982272 | en_ZA |
dc.identifier.citation | Feng, H., Gusev, A., Pasaniuc, B. et al. Transcriptome-wide association study of breast cancer risk by estrogen-receptor status. Genetic Epidemiology 2020;44(5): 442-468. doi:10.1002/gepi.22288. | en_ZA |
dc.identifier.issn | 0741-0395 (print) | |
dc.identifier.issn | 1098-2272 (online) | |
dc.identifier.other | 10.1002/gepi.22288 | |
dc.identifier.uri | http://hdl.handle.net/2263/80193 | |
dc.language.iso | en | en_ZA |
dc.publisher | Wiley | en_ZA |
dc.rights | © 2020 The Authors. Genetic Epidemiology published by Wiley Periodicals, Inc. This is an open access article under the terms of the Creative Commons Attribution License. | en_ZA |
dc.subject | Breast cancer subtype | en_ZA |
dc.subject | Causal gene | en_ZA |
dc.subject | Transcriptome-wide association studies (TWAS) | en_ZA |
dc.subject | Genome-wide association studies (GWAS) | en_ZA |
dc.title | Transcriptome-wide association study of breast cancer risk by estrogen-receptor status | en_ZA |
dc.type | Article | en_ZA |