Persistently elevated expression of systemic, soluble co-inhibitory immune checkpoint molecules in people living with HIV before and one year after antiretroviral therapy
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Date
Authors
Labuschagne Naidoo, Robyn-Brooke
Theron, Annette J.
Anderson, Ronald
Tintinger, Gregory Ronald
Rossouw, Theresa M.
Journal Title
Journal ISSN
Volume Title
Publisher
MDPI
Abstract
Please read abstract in article.
Description
DATA AVAILABILITY STATEMENT: The data that support the findings of this study are available from the
corresponding author upon reasonable request.
SUPPORTING INFORMATION: TABLE S1: Comparison of soluble immune checkpoint levels between female and male PLWH before ART; TABLE S2: Comparison of soluble immune checkpoint levels between female and male PLWH after 12 months of ART; TABLE S3: Comparison of the change in soluble immune checkpoint levels before and after 12 months of ART between tobacco-users and non-users; TABLE S4: Correlations between age and soluble immune checkpoint molecules before treatment in PLWH.
SUPPORTING INFORMATION: TABLE S1: Comparison of soluble immune checkpoint levels between female and male PLWH before ART; TABLE S2: Comparison of soluble immune checkpoint levels between female and male PLWH after 12 months of ART; TABLE S3: Comparison of the change in soluble immune checkpoint levels before and after 12 months of ART between tobacco-users and non-users; TABLE S4: Correlations between age and soluble immune checkpoint molecules before treatment in PLWH.
Keywords
Antiretroviral treatment, Co-inhibitory immune checkpoints, CTLA-4, LAG-3, PD-1, PD-L1, TIM-3, SDG-03: Good health and well-being, SDG-09: Industry, innovation and infrastructure, Antiretroviral therapy (ART), Human immunodeficiency virus (HIV)
Sustainable Development Goals
SDG-03:Good heatlh and well-being
SDG-09: Industry, innovation and infrastructure
SDG-09: Industry, innovation and infrastructure
Citation
Labuschagne Naidoo, R.-B.;
Steel, H.C.; Theron, A.J.; Anderson, R.;
Tintinger, G.R.; Rossouw, T.M.
Persistently Elevated Expression of
Systemic, Soluble Co-Inhibitory
Immune Checkpoint Molecules in
People Living with HIV before and
One Year after Antiretroviral Therapy.
Pathogens 2024, 13, 540. https://doi.org/10.3390/pathogens13070540.