Transmission of jaagsiekte (ovine pulmonary adenomatosis) by means of a permanent epithelial cell line established from affected lungs
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Date
Authors
Coetzee, S.
Els, H.J.
Verwoerd, Daniel Wynand
Journal Title
Journal ISSN
Volume Title
Publisher
Published by The Government Printer, Pretoria
Abstract
An epithelial cell line, designated JS-15. 4, has been established in culture from jaagsiekte lesions
and subcultured in vitro for almost 2 years. It exhibits morphological and other features of transformed
cells and has been shown by electron microscopy to consist of type B ovine alveolar epithelial
cells. Jaagsiekte was successfully transmitted to 3 new-born lambs by the intratracheal injection of
cells following immunosuppressive treatment with either anti-thymocyte immunoglobulin alone or
combined with anti-macrophage immunoglobulin. Incubation periods as short as 10 weeks were
recorded. Evidence was also obtained that natural transmission may result from the inhalation of
viable cells.
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Keywords
Veterinary medicine
Sustainable Development Goals
Citation
Coetzee, S, Els, HJ & Verwoerd, DW 1976, 'Transmission of jaagsiekte (ovine pulmonary adenomatosis) by means of a permanent epithelial cell line established from affected lungs’, The Onderstepoort Journal of Veterinary Research, vol. 43, no. 3, pp. 133-141.