A novel preparation method for porous hemi-spherical bio-polymeric microparticles

dc.contributor.advisorRolfes, H.en
dc.contributor.emailknaidoo3@csir.co.zaen
dc.contributor.postgraduateNaidoo, Kerschen
dc.date.accessioned2013-09-07T03:55:20Z
dc.date.available2011-07-14en
dc.date.available2013-09-07T03:55:20Z
dc.date.created2011-04-15en
dc.date.issued2011-07-14en
dc.date.submitted2011-07-11en
dc.descriptionDissertation (MEng)--University of Pretoria, 2011.en
dc.description.abstractA modified oil-in-water emulsion process was developed to produce novel microporous hemi-spherical polycaprolactone (PCL) microparticles called “hemi-shells”. Through the addition of a porogen such as sodium bicarbonate into the PCL-dichloromethane oil phase and emulsification in an acidic polyvinyl alcohol aqueous phase, microporous hemi-shells formed as dichloromethane evaporated. Carbon dioxide gas evolution from the porogen reaction with the acidic aqueous phase created particles with an externally microporous shell and a large internal cavity. The hemi-shells were characterized by various methods, including scanning electron microscopy and optical microscopy which were specifically used to quantify the hemi-shell yield. The final number-average particle yield of the optimised manufacturing method for particle manufacture in the 50-200 micron size range was 84%. The number-average hemi-shell yield in the same size range was 41%. These novel microparticles have potential applications in tissue engineering and drug deliveryen
dc.description.availabilityunrestricteden
dc.description.departmentChemical Engineeringen
dc.identifier.citationNaidoo, K 2010, A novel preparation method for porous hemi-spherical bio-polymeric microparticles, MEng dissertation, University of Pretoria, Pretoria, viewed yymmdd < http://hdl.handle.net/2263/26216 >en
dc.identifier.otherE11/323/gmen
dc.identifier.upetdurlhttp://upetd.up.ac.za/thesis/available/etd-07112011-170301/en
dc.identifier.urihttp://hdl.handle.net/2263/26216
dc.language.isoen
dc.publisherUniversity of Pretoriaen_ZA
dc.rights© 2010, University of Pretoria. All rights reserved. The copyright in this work vests in the University of Pretoria. No part of this work may be reproduced or transmitted in any form or by any means, without the prior written permission of the University of Pretoria.en
dc.subjectMicroparticlesen
dc.subjectPorogenen
dc.subjectOil-in-wateren
dc.subjectCavityen
dc.subjectMicroporousen
dc.subjectTissue engineeringen
dc.subjectDrug deliveryen
dc.subjectHemi-shellsen
dc.subjectPolycaprolactoneen
dc.subjectEmulsionen
dc.subjectUCTDen_US
dc.titleA novel preparation method for porous hemi-spherical bio-polymeric microparticlesen
dc.typeDissertationen

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