What is the main driver of ageing in long-lived winter honeybees : antioxidant enzymes, innate immunity, or vitellogenin?

dc.contributor.authorAurori, Cristian M.
dc.contributor.authorButtstedt, Anja
dc.contributor.authorDezmirean, Daniel S.
dc.contributor.authorMărghitaş, Liviu A.
dc.contributor.authorMoritz, Robin F.A.
dc.contributor.authorErler, Silvio
dc.date.accessioned2014-10-09T05:15:30Z
dc.date.issued2014-06
dc.description.abstractSenescence or ageing in invertebrates is only partly unscrambled. Up to now five different theories deal with explaining the biology of ageing. Most likely physiology, genetic predestination and the impact of the environment form the image of ageing in individuals and groups. Social insects, especially the honeybee Apis mellifera, present the best model system to study developmentally related ageing, because high phenotypic plasticity makes the worker caste useful to dissolve remaining questions. Here, we used long-lived winter honeybee workers and measured transcriptional changes of 14 antioxidative enzymes, immunity and ageing-related (Insulin/insulin-like growth factor signalling-pathway) genes at two time points during hibernation. Additionally, the bees received a bacterial infection to see ageing and infection associated immunity changes. Gene expression levels for each group of target genes revealed that ageing had a much higher impact than the bacterial infections, notably for immunity related genes. Antimicrobial peptide and antioxidative enzyme genes were significantly up-regulated in aged worker honeybees independent of bacterial infections. Vitellogenin and IlP-1, known ageing markers, were contrary regulated with increasing vitellogenin levels during ageing. The increased antioxidative enzyme and antimicrobial peptide gene expression may have a positive and also protective effect during ageing in hibernating worker honeybees.en_US
dc.description.librarianhb2014en_US
dc.description.urihttp://biomedgerontology.oxfordjournals.org/en_US
dc.identifier.citationAurori, CM, Buttstedt, A, Dezmirean, DS, Mǎrghitaş, LA., Moritz, RFA & Erler, S 2014, 'What is the main driver of ageing in long-lived winter honeybees : antioxidant enzymes, innate immunity, or vitellogenin?', Journals of Gerontology - Series A Biological Sciences and Medical Sciences, vol. 69, no. 6, pp. 633-639.en_US
dc.identifier.issn1079-5006 (print)
dc.identifier.issn1758-535X (online)
dc.identifier.otherdoi: 10.1093/gerona/glt134
dc.identifier.urihttp://hdl.handle.net/2263/42306
dc.language.isoenen_US
dc.publisherOxford University Pressen_US
dc.rights© The Author 2013. Published by Oxford University Press on behalf of The Gerontological Society of America. All rights reserved. This is a pre-copy-editing, author-produced PDF of an article accepted for publication in Journals of Gerontology - Series A Biological Sciences and Medical Sciences following peer review. The definitive publisher-authenticated version Journals of Gerontology - Series A Biological Sciences and Medical Sciences, vol. 69, no. 6, pp.633-639, 2014. doi: 10.1093/gerona/glt134 is available online at : http://biomedgerontology.oxfordjournals.org/.en_US
dc.subjectAntioxidative enzymesen_US
dc.subjectHoneybee (Apis mellifera)en_US
dc.subjectInnate immunityen_US
dc.subjectSenescenceen_US
dc.subjectSocial insecten_US
dc.titleWhat is the main driver of ageing in long-lived winter honeybees : antioxidant enzymes, innate immunity, or vitellogenin?en_US
dc.typePostprint Articleen_US

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