Vitamin D status in dogs with babesiosis

dc.contributor.authorDvir, Eran
dc.contributor.authorRosa, Chantal T.
dc.contributor.authorHandel, Ian
dc.contributor.authorMellanby, Richard J.
dc.contributor.authorSchoeman, Johan P.
dc.date.accessioned2019-06-24T10:07:18Z
dc.date.available2019-06-24T10:07:18Z
dc.date.issued2019-03-28
dc.description.abstractCanine babesiosis is a virulent infection of dogs in South Africa caused principally by Babesia rossi. Hypovitaminosis D has been reported in a wide range of infectious diseases in humans and dogs, and low vitamin D status has been associated with poor clinical outcomes. However, the relationship between vitamin D status and canine babesiosis has not been investigated. The objective of this study was to examine the relationship between the presence and severity of B. rossi infection and vitamin D status of infected dogs. Owners with dogs with a confirmed diagnosis of B. rossi infection and of healthy control dogs were invited to enrol onto the study. Vitamin D status was assessed by measurement of serum concentrations of the major circulating vitamin D metabolite, 25-hydroxyvitamin D (25[OH]D). Dogs with babesiosis (n = 34) had significantly lower mean serum 25(OH)D concentrations than healthy dogs (n = 24) (37.76 ± 21.25 vs. 74.2 ± 20.28 nmol/L). The effect of babesiosis on serum 25(OH)D concentrations was still significant after adjusting for any effect of age, body weight and sex. There was a negative relationship between serum 25(OH) D concentrations and disease severity in dogs with babesiosis. Serum concentrations of creatinine and alanine aminotransferase and time to last meal were not associated with serum 25(OH)D concentrations in dogs with babesiosis. In conclusion, dogs with Babesia rossi infections had lower serum 25(OH)D concentrations than healthy dogs. The inverse correlation between 25(OH)D concentrations and the clinical severity score indicate that hypovitaminosis D might be a helpful additional indicator of disease severity.en_ZA
dc.description.departmentCompanion Animal Clinical Studiesen_ZA
dc.description.librarianam2019en_ZA
dc.description.urihttp://www.ojvr.orgen_ZA
dc.identifier.citationDvir, E., Rosa, C., Handel, I., Mellanby R.J. & Schoeman, J.P., 2019, ‘Vitamin D status in dogs with babesiosis’, Onderstepoort Journal of Veterinary Research 86(1), a1644. https://DOI.org/10.4102/ojvr.v86i1.1644.en_ZA
dc.identifier.issn0030-2465 (print)
dc.identifier.issn2219-0635 (online)
dc.identifier.other10.4102/ojvr.v86i1.1644
dc.identifier.urihttp://hdl.handle.net/2263/70273
dc.language.isoenen_ZA
dc.publisherAOSIS OpenJournalsen_ZA
dc.rights© 2019. The Authors. Licensee: AOSIS. This work is licensed under the Creative Commons Attribution License.en_ZA
dc.subjectVitamin Den_ZA
dc.subject25-Hydroxyvitamin Den_ZA
dc.subjectBabesiosisen_ZA
dc.subjectBabesia rossien_ZA
dc.subjectDogs (Canis familiaris)en_ZA
dc.subjectSouth Africa (SA)en_ZA
dc.subjectCanine babesiosisen_ZA
dc.subjectHypovitaminosis Den_ZA
dc.titleVitamin D status in dogs with babesiosisen_ZA
dc.typeArticleen_ZA

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