Mixed adenoneuroendocrine carcinoma of the tongue arising within a congenital enteric cyst
dc.contributor.author | Ligthelm, Louis J. | |
dc.contributor.author | Bunn, Belinda Kathleen | |
dc.contributor.author | Raubenheimer, E.J. (Erich) | |
dc.contributor.author | Van Heerden, Willem Francois Petrus | |
dc.contributor.email | willie.vanheerden@up.ac.za | en_ZA |
dc.date.accessioned | 2018-05-24T12:43:48Z | |
dc.date.issued | 2018-05 | |
dc.description.abstract | BACKGROUND : Primary intestinal‐type adenocarcinoma of the tongue is rare. This represents the first reported case of a primary mixed adenoneuroendocrine carcinoma (MANEC) of the tongue arising within a congenital enteric cyst. METHODS : A 52‐year‐old man presented with a midline tongue mass that was connected to the mucosal surface with an epithelial‐lined sinus tract. orphological examination and immunohistochemical profiling of the neoplasm were performed. RESULTS : Histopathological evaluation showed a primary MANEC arising within a preexisting congenital enteric cyst, comprising both adenocarcinoma and neuroendocrine components. The adenocarcinoma had a colonic‐type morphology and coexpressed CK7, CK20, and CDX2. Imaging and colonoscopy excluded a distant primary colorectal neoplasm. CONCLUSION : The association of primary MANEC of the tongue with a gastrointestinal heterotopic cyst supports an origin from entrapped endodermal elements as opposed to salivary duct origin. This case raises the awareness of a rare yet prognostically important complication of a gastrointestinal heterotopic cyst. | en_ZA |
dc.description.department | Oral Pathology and Oral Biology | en_ZA |
dc.description.embargo | 2019-05-01 | |
dc.description.librarian | hj2018 | en_ZA |
dc.description.uri | http://wileyonlinelibrary.com/journal/hed | en_ZA |
dc.identifier.citation | Ligthelm LJ, Bunn BK, Raubenheimer EJ, Heerden WFP. Mixed adenoneur-oendocrine carcinoma of the tongue arising within a congenital enteric cyst. Head & Neck. 2018;40:E53–E57. https://doi.org/10.1002/hed.25117. | en_ZA |
dc.identifier.issn | 1043-3074 (print) | |
dc.identifier.issn | 1097-0347 (online) | |
dc.identifier.other | 10.1002/hed.25117 | |
dc.identifier.uri | http://hdl.handle.net/2263/65009 | |
dc.language.iso | en | en_ZA |
dc.publisher | Wiley | en_ZA |
dc.rights | © 2018 Wiley Periodicals, Inc. This is the pre-peer reviewed version of the following article : Mixed adenoneur-oendocrine carcinoma of the tongue arising within a congenital enteric cyst, Head and Neck, vol. 40, pp. E53–E57, 2018, doi : 10.1002/hed.25117. The definite version is available at : https://http://wileyonlinelibrary.com/journal/hed. | en_ZA |
dc.subject | Mixed adenoneuroendocrine carcinoma (MANEC) | en_ZA |
dc.subject | Tongue | en_ZA |
dc.subject | Congenital enteric cyst | en_ZA |
dc.subject | Histogenesis | en_ZA |
dc.subject | Rare | en_ZA |
dc.subject | Tract | en_ZA |
dc.subject | Entity | en_ZA |
dc.subject | Gastrointestinal heterotopic cyst | en_ZA |
dc.subject | Colonic‐type adenocarcinoma | en_ZA |
dc.subject | Primary tongue adenocarcinoma | en_ZA |
dc.title | Mixed adenoneuroendocrine carcinoma of the tongue arising within a congenital enteric cyst | en_ZA |
dc.type | Postprint Article | en_ZA |