Mixed adenoneuroendocrine carcinoma of the tongue arising within a congenital enteric cyst

dc.contributor.authorLigthelm, Louis J.
dc.contributor.authorBunn, Belinda Kathleen
dc.contributor.authorRaubenheimer, E.J. (Erich)
dc.contributor.authorVan Heerden, Willem Francois Petrus
dc.contributor.emailwillie.vanheerden@up.ac.zaen_ZA
dc.date.accessioned2018-05-24T12:43:48Z
dc.date.issued2018-05
dc.description.abstractBACKGROUND : Primary intestinal‐type adenocarcinoma of the tongue is rare. This represents the first reported case of a primary mixed adenoneuroendocrine carcinoma (MANEC) of the tongue arising within a congenital enteric cyst. METHODS : A 52‐year‐old man presented with a midline tongue mass that was connected to the mucosal surface with an epithelial‐lined sinus tract. orphological examination and immunohistochemical profiling of the neoplasm were performed. RESULTS : Histopathological evaluation showed a primary MANEC arising within a preexisting congenital enteric cyst, comprising both adenocarcinoma and neuroendocrine components. The adenocarcinoma had a colonic‐type morphology and coexpressed CK7, CK20, and CDX2. Imaging and colonoscopy excluded a distant primary colorectal neoplasm. CONCLUSION : The association of primary MANEC of the tongue with a gastrointestinal heterotopic cyst supports an origin from entrapped endodermal elements as opposed to salivary duct origin. This case raises the awareness of a rare yet prognostically important complication of a gastrointestinal heterotopic cyst.en_ZA
dc.description.departmentOral Pathology and Oral Biologyen_ZA
dc.description.embargo2019-05-01
dc.description.librarianhj2018en_ZA
dc.description.urihttp://wileyonlinelibrary.com/journal/heden_ZA
dc.identifier.citationLigthelm LJ, Bunn BK, Raubenheimer EJ, Heerden WFP. Mixed adenoneur-oendocrine carcinoma of the tongue arising within a congenital enteric cyst. Head & Neck. 2018;40:E53–E57. https://doi.org/10.1002/hed.25117.en_ZA
dc.identifier.issn1043-3074 (print)
dc.identifier.issn1097-0347 (online)
dc.identifier.other10.1002/hed.25117
dc.identifier.urihttp://hdl.handle.net/2263/65009
dc.language.isoenen_ZA
dc.publisherWileyen_ZA
dc.rights© 2018 Wiley Periodicals, Inc. This is the pre-peer reviewed version of the following article : Mixed adenoneur-oendocrine carcinoma of the tongue arising within a congenital enteric cyst, Head and Neck, vol. 40, pp. E53–E57, 2018, doi : 10.1002/hed.25117. The definite version is available at : https://http://wileyonlinelibrary.com/journal/hed.en_ZA
dc.subjectMixed adenoneuroendocrine carcinoma (MANEC)en_ZA
dc.subjectTongueen_ZA
dc.subjectCongenital enteric cysten_ZA
dc.subjectHistogenesisen_ZA
dc.subjectRareen_ZA
dc.subjectTracten_ZA
dc.subjectEntityen_ZA
dc.subjectGastrointestinal heterotopic cysten_ZA
dc.subjectColonic‐type adenocarcinomaen_ZA
dc.subjectPrimary tongue adenocarcinomaen_ZA
dc.titleMixed adenoneuroendocrine carcinoma of the tongue arising within a congenital enteric cysten_ZA
dc.typePostprint Articleen_ZA

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