Isolation and characterization of two acaricidal compounds from Calpurnia aurea subsp. aurea (Fabaceae) leaf extract
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Date
Authors
Adenubi, O.T. (Olubukola Tolulope)
Abdalla, Muna Ali
Ahmed, Aroke Shahid
Njoya, Emmanuel Mfotie
McGaw, Lyndy Joy
Eloff, Jacobus Nicolaas
Naidoo, Vinny
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Volume Title
Publisher
Springer
Abstract
The menace caused by ticks and tick-borne diseases is a major limitation to the livestock industry in Africa. The high costs and non-availability of synthetic, chemical acaricides to resource-limited farmers, resistance of ticks to available acaricides and residue problems in meat and milk consumed by humans further complicate matters. The use of plant extracts as a possible source of new acaricides has received much interest in the last decade. In our endeavour to discover natural acaricidal compounds, tick toxicant bioassays were conducted and the chloroform fraction of Calpurnia aurea ethanol leaf extract had good acaricidal activity. Further purification of the fraction revealed two flavonoids, isolated from C. aurea for the first time. These flavonoids were characterized as apigenin-7-O-β-d-glycoside and isorhoifolin by means of NMR spectroscopic and mass spectrometry analysis. Isorhoifolin was the most potent compound (LC50 = 0.65 mg/ml), was not cytotoxic and should be further investigated for its potential as an acaricidal agent.
Description
Keywords
Acaricidal activity, Plant extracts, Flavonoids, Apigenin-7-O-β-d-glycoside, Isorhoifolin
Sustainable Development Goals
Citation
Adenubi, O.T., Ali Abdalla, M., Ahmed, A.S. et al. Isolation and characterization of two acaricidal compounds from Calpurnia aurea subsp. aurea (Fabaceae) leaf extract. Experimental and Applied Acarology (2018) 75: 345-354. https://doi.org/10.1007/s10493-018-0269-4.