Brown coal derived humate inhibits contact hypersensitivity : an efficacy, toxicity and teratogenicity study in rats

dc.contributor.authorJansen van Rensburg, Connie E.
dc.contributor.authorSnyman, Jacques Rene
dc.contributor.authorMokoele, T.L.
dc.contributor.authorCromarty, Allan Duncan
dc.contributor.emailcmedlen@postillion.up.ac.zaen
dc.date.accessioned2008-01-17T13:13:24Z
dc.date.available2008-01-17T13:13:24Z
dc.date.issued2007-10
dc.description.abstractOBJECTIVES:The effects of two humate products were compared to that of prednisolone on a contact hypersensitivity rat model. METHODS: Rats, sensitized with dinitrofluorobenzene (DNFB), were placed on a daily oral treatment of 61mg/kg BW of humate derived from either leonardite or bituminous coal or on prednisolone at one mg/kg BW and challenged 6 days later with a topical application of DNFB to the right ear. The inflamed ears were measured daily. In a toxicity study rats were exposed to daily oral treatment of leonardite humate at 1,000 mg/kg BW for 1 month. A teratogenicity study was done where pregnant rats were treated with 500 mg/kg BW on days 5 to 17 of pregnancy. RESULTS: Only the leonardite humate compared favourably with prednisolone in suppressing contact hypersensitivity. No signs of toxicity were observed and weight gain was normal during the 6-day and 1month treatments and during the teratogenicity study with the leonardite humate. However, the rats on the other two products experienced slower weight gain. CONCLUSION: The identification of a naturally occurring nontoxic compound with anti-inflammatory activity is exciting and merits further evaluation in the treatment of patients suffering from inflammatory conditions.en
dc.format.extent217002 bytes
dc.format.mimetypeapplication/pdf
dc.identifier.citationVan Rensburg, CEJ, Snyman, JR, Mokoele, T & Cromarty, AD 2007, 'Brown coal derived humate inhibits contact hypersensitivity : an efficacy, toxicity and teratogenicity study in rats', Inflammation, vol. 30, no. 5, pp. 148-152. [http://www.springerlink.com/content/0360-3997]en
dc.identifier.issn1573-2576
dc.identifier.other10.1007/s10753-007-9031-5
dc.identifier.urihttp://hdl.handle.net/2263/4248
dc.language.isoenen
dc.publisherSpringeren
dc.rightsSpringer. The original publication is available at www.springerlink.comen
dc.subjectPotassium humateen
dc.subjectAnti-inflammatoryen
dc.subjectContact hypersensitivityen
dc.subjectSafety profileen
dc.subject.lcshMedicine, Experimental
dc.subject.lcshRats
dc.subject.lcshBituminous coal
dc.subject.lcshAnti-inflammatory agents
dc.titleBrown coal derived humate inhibits contact hypersensitivity : an efficacy, toxicity and teratogenicity study in ratsen
dc.typePostprint Articleen

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