Occlusion of insulin delivery due to bubble formation in infusion pump therapy

dc.contributor.authorDenuren, Ayodeji
dc.contributor.authorGyuricsko, Eric
dc.contributor.authorDiawara, Norou
dc.date.accessioned2016-07-18T10:51:07Z
dc.date.available2016-07-18T10:51:07Z
dc.date.issued2015
dc.description.abstractPapers presented to the 11th International Conference on Heat Transfer, Fluid Mechanics and Thermodynamics, South Africa, 20-23 July 2015.en_ZA
dc.description.abstractVarious models of insulin pumps were used in this in-vitro experimental study to investigate the delivery performance when operating at various pre-set basal flow rates. The effect of insulin type on the measured delivery performance was also investigated by using three different types of insulin derivatives, namely: Humalog (“lispro”), Novolog (“aspart”), and Apidra (“glulisine”). Experiments were performed in a controlled laboratory environment in which data were collected using an automated computerized data acquisition setup, with temperature control to simulate body contact, and agitation to simulate typical activity levels. Each experiment ran for up to 5 days. Statistical analysis was performed on the data collected to determine significant differences and deviations in insulin delivery rates that might be due to factors such as: pump type, the set basal flow rate, insulin type, vibration, and possible insulin occlusion due to air bubble formation within the infusion line. Results of the study showed that insulin occlusion due to bubble formation occurred in about 7% of experimental runs and could last for 8 to 10 hours, depending on the flow rate and other conditions.en_ZA
dc.description.librarianam2016en_ZA
dc.format.mediumPDFen_ZA
dc.identifier.citationDemuren, A, Gyuricsko, E & Diawara, N 2015, 'Occlusion of insulin delivery due to bubble formation in infusion pump therapy', Paper presented to the 11th International Conference on Heat Transfer, Fluid Mechanics and Thermodynamics, Florida, 20-23 July 2015.en_ZA
dc.identifier.isbn97817759206873
dc.identifier.urihttp://hdl.handle.net/2263/55887
dc.language.isoenen_ZA
dc.publisherInternational Conference on Heat Transfer, Fluid Mechanics and Thermodynamicsen_ZA
dc.rights© 2015 University of Pretoria. All rights reserved. The copyright in this work vests in the University of Pretoria. No part of this work may be reproduced or transmitted in any form or by any means, without the prior written permission of the University of Pretoria.en_ZA
dc.subjectInsulin pumpsen_ZA
dc.subjectDelivery performanceen_ZA
dc.subjectExperimentsen_ZA
dc.subjectInsulin occlusionen_ZA
dc.titleOcclusion of insulin delivery due to bubble formation in infusion pump therapyen_ZA
dc.typePresentationen_ZA

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