Phytochemical analysis and in-vitro anti-African swine fever virus activity of extracts and fractions of Ancistrocladus uncinatus, Hutch and Dalziel (Ancistrocladaceae)

dc.contributor.authorFasina, Folorunso Oludayo
dc.contributor.authorOlaokun, Oyinlola Oluwunmi
dc.contributor.authorOladipo, Olusola O.
dc.contributor.authorFasina, Margaret M.
dc.contributor.authorMakinde, Adesoji A.
dc.contributor.authorHeath, Livio Edward
dc.contributor.authorBastos, Armanda D.S.
dc.contributor.emaildayo.fasina@up.ac.zaen
dc.date.accessioned2014-01-24T08:56:16Z
dc.date.available2014-01-24T08:56:16Z
dc.date.issued2013-06-19
dc.description.abstractBACKGROUND: African swine fever (ASF), a highly contagious fatal acute haemorrhagic viral disease of pigs currently has no treatment or vaccination protocol and it threatens the pig industry worldwide. Recent outbreaks were managed by farmers with ethnoveterinary preparations with various claims of effectiveness. RESULTS: We identified 35 compounds using GC-MS protocol and ASF virus (NIG 99) was significantly reduced by some extracts and fractions of the plant. However, the plant was poorly extracted by water and cytotoxicity was found to be a major problem with the use of the plant since its extracts also reduced the primary cells used in the assay. CONCLUSION: It is confirmed that the plant has antiviral potentials against ASF virus and farmers’ claims seem to have certain degree of veracity, but finding the best means of exploring the potential of the plant while reducing its cytotoxic effect in-vitro and in-vivo will be necessary.en
dc.description.librarianab2014
dc.description.sponsorshipThe Executive Secretary, Agricultural Research Council of Nigeria, Abuja for part funding of this project under the Project Code 025060410100000 (Development of rapid and effective Diagnostic and Control tools for African Swine Fever)en
dc.description.urihttp://www.biomedcentral.com/1746-6148/9/120en
dc.identifier.citationFasina et al.: Phytochemical analysis and in-vitro anti-African swine fever virus activity of extracts and fractions of Ancistrocladus uncinatus, Hutch and Dalziel (Ancistrocladaceae). BMC Veterinary Research 2013 9:120.en
dc.identifier.issn1746-6148
dc.identifier.other10.1186/1746-6148-9-120
dc.identifier.other16416667800
dc.identifier.otherH-9699-2013
dc.identifier.urihttp://hdl.handle.net/2263/33083
dc.language.isoenen
dc.publisherBioMed Centralen
dc.relation.requiresAdobe Acrobat Readeren
dc.rights© 2013 Fasina et al.; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution Licenseen
dc.subjectAncistrocladus uncinatusen
dc.subjectAntiviralen
dc.subject.lcshAfrican swine fever virusen
dc.subject.lcshSwine -- Diseasesen
dc.subject.lcshPlant extractsen
dc.titlePhytochemical analysis and in-vitro anti-African swine fever virus activity of extracts and fractions of Ancistrocladus uncinatus, Hutch and Dalziel (Ancistrocladaceae)en
dc.typeArticleen

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