Consequences of HIV infection in the bone marrow niche
| dc.contributor.author | Herd, Candice | |
| dc.contributor.author | Mellet, Juanita | |
| dc.contributor.author | Mashingaidze, Nester | |
| dc.contributor.author | Durandt, Chrisna | |
| dc.contributor.author | Pepper, Michael Sean | |
| dc.contributor.email | michael.pepper@up.ac.za | en_US |
| dc.date.accessioned | 2024-06-13T09:30:40Z | |
| dc.date.available | 2024-06-13T09:30:40Z | |
| dc.date.issued | 2023-07-11 | |
| dc.description.abstract | Dysregulation of the bone marrow niche resulting from the direct and indirect effects of HIV infection contributes to haematological abnormalities observed in HIV patients. The bone marrow niche is a complex, multicellular environment which functions primarily in the maintenance of haematopoietic stem/ progenitor cells (HSPCs). These adult stem cells are responsible for replacing blood and immune cells over the course of a lifetime. Cells of the bone marrow niche support HSPCs and help to orchestrate the quiescence, self-renewal and differentiation of HSPCs through chemical and molecular signals and cell-cell interactions. This narrative review discusses the HIV-associated dysregulation of the bone marrow niche, as well as the susceptibility of HSPCs to infection by HIV. | en_US |
| dc.description.department | Immunology | en_US |
| dc.description.librarian | am2024 | en_US |
| dc.description.sdg | SDG-03:Good heatlh and well-being | en_US |
| dc.description.sponsorship | The NRF-DAAD program, the University of Pretoria, the National Research Foundation, the Bill and Melinda Gates Foundation and the South African Medical Research Council. | en_US |
| dc.description.uri | http://www.frontiersin.org/Immunology | en_US |
| dc.identifier.citation | Herd, C.L., Mellet, J., Mashingaidze, T., Durandt, C. & Pepper, M.S. (2023) Consequences of HIV infection in the bone marrow niche. Frontiers in Immunology. 14:1163012. DOI: 10.3389/fimmu.2023.1163012. | en_US |
| dc.identifier.issn | 1664-3224 (online) | |
| dc.identifier.other | 10.3389/fimmu.2023.1163012 | |
| dc.identifier.uri | http://hdl.handle.net/2263/96468 | |
| dc.language.iso | en | en_US |
| dc.publisher | Frontiers Media | en_US |
| dc.rights | © 2023 Herd, Mellet, Mashingaidze, Durandt and Pepper. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). | en_US |
| dc.subject | Bone marrow niche | en_US |
| dc.subject | Haematopoiesis | en_US |
| dc.subject | Dysregulation | en_US |
| dc.subject | Human immunodeficiency virus (HIV) | en_US |
| dc.subject | Haematopoietic stem/ progenitor cells (HSPCs) | en_US |
| dc.subject | SDG-03: Good health and well-being | en_US |
| dc.title | Consequences of HIV infection in the bone marrow niche | en_US |
| dc.type | Article | en_US |