The role of aDNA in understanding the coevolutionary patterns of human sexually transmitted infections

dc.contributor.authorPimenoff, Ville N.
dc.contributor.authorHouldcroft, Charlotte J.
dc.contributor.authorRifkin, Riaan F.
dc.contributor.authorUnderdown, Simon
dc.date.accessioned2018-09-20T06:51:33Z
dc.date.available2018-09-20T06:51:33Z
dc.date.issued2018-07
dc.description.abstractAnalysis of pathogen genome data sequenced from clinical and historical samples has made it possible to perform phylogenetic analyses of sexually transmitted infections on a global scale, and to estimate the diversity, distribution, and coevolutionary host relationships of these pathogens, providing insights into pathogen emergence and disease prevention. Deep-sequenced pathogen genomes from clinical studies and ancient samples yield estimates of within-host and between-host evolutionary rates and provide data on changes in pathogen genomic stability and evolutionary responses. Here we examine three groups of pathogens transmitted mainly through sexual contact between modern humans to provide insight into ancient human behavior and history with their pathogens. Exploring ancient pathogen genomic divergence and the ancient viral-host parallel evolutionary histories will help us to reconstruct the origin of present-day geographical distribution and diversity of clinical pathogen infections, and will hopefully allow us to foresee possible environmentally induced pathogen evolutionary responses. Lastly, we emphasize that ancient pathogen DNA research should be combined with modern clinical pathogen data, and be equitable and provide advantages for all researchers worldwide, e.g., through shared data.en_ZA
dc.description.departmentBiochemistryen_ZA
dc.description.departmentGeneticsen_ZA
dc.description.departmentMicrobiology and Plant Pathologyen_ZA
dc.description.librarianam2018en_ZA
dc.description.sponsorshipV.N.P. was funded by the European Society of Clinical Microbiology and Infectious Diseases grant and the Ministry of Health, Government of Catalonia (grant SLT002/16/00496). C.J.H. was funded by the NIHR Cambridge Biomedical Research Centre Anti-Microbial Resistance theme. R.F.R. was funded by a National Geographic Society/Waitt Foundation Scientific Exploration Grant (Nr. W420–15) and the University of Pretoria. S.J.U was funded by Oxford Brookes University.en_ZA
dc.description.urihttp://www.mdpi.com/journal/genesen_ZA
dc.identifier.citationPimenoff, V.N., Houldcroft, C.J., Rifkin, R.F. et al. 2018, 'The role of aDNA in understanding the coevolutionary patterns of human sexually transmitted infections', Genes, vol. 9, art. 317, pp. 1-14.en_ZA
dc.identifier.issn2073-4425 (online)
dc.identifier.other10.3390/genes9070317
dc.identifier.urihttp://hdl.handle.net/2263/66600
dc.language.isoenen_ZA
dc.publisherMDPIen_ZA
dc.rights© 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license.en_ZA
dc.subjectEvolutionary medicineen_ZA
dc.subjectPapillomavirusesen_ZA
dc.subjectHerpesvirusesen_ZA
dc.subjectEctoparasitesen_ZA
dc.subjectVirus-host coevolutionen_ZA
dc.subjectDivergenceen_ZA
dc.subjectHost-switchen_ZA
dc.subjectHominin evolutionen_ZA
dc.subjectSexually transmitted infection (STI)en_ZA
dc.titleThe role of aDNA in understanding the coevolutionary patterns of human sexually transmitted infectionsen_ZA
dc.typeArticleen_ZA

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