Anaesthetic induction and recovery characteristics of a diazepam-ketamine combination compared with propofol in dogs

dc.contributor.authorFerreira, Jacques Paul
dc.contributor.authorDzikiti, Brighton T.
dc.contributor.authorZeiler, Gareth Edward
dc.contributor.authorBuck, Roxanne Kate
dc.contributor.authorNevill, Bruce Guy
dc.contributor.authorGummow, Bruce
dc.contributor.authorBester, Lynette
dc.contributor.emailjp.ferreira@up.ac.zaen_ZA
dc.date.accessioned2015-08-31T07:40:13Z
dc.date.available2015-08-31T07:40:13Z
dc.date.issued2015-06-01
dc.description.abstractInduction of anaesthesia occasionally has been associated with undesirable behaviour in dogs. High quality of induction of anaesthesia with propofol has been well described while in contrast variable induction and recovery quality has been associated with diazepam-ketamine. In this study, anaesthetic induction and recovery characteristics of diazepam-ketamine combination with propofol alone were compared in dogs undergoing elective orchidectomy. Thirty-six healthy adult male dogs were used. After habitus scoring (simple descriptive scale [SDS]), the dogs were sedated with morphine and acepromazine. Forty minutes later a premedication score (SDS) was allocated and general anaesthesia was induced using a combination of diazepam-ketamine (Group D/K) or propofol (Group P) and maintained with isoflurane. Scores for the quality of induction, intubation and degree of myoclonus were allocated (SDS). Orchidectomy was performed after which recovery from anaesthesia was scored (SDS) and times to extubation and standing were recorded. Data were analysed using descriptive statistics and Kappa Reliability and Kendall Tau B tests. Both groups were associated with acceptable quality of induction and recovery from anaesthesia. Group P, however, was associated with a poorer quality of induction (p = 0.014), prolonged induction period (p = 0.0018) and more pronounced myoclonus (p = 0.003), but had better quality of recovery (p = 0.000002) and shorter recovery times (p = 0.035) compared with Group D/K. Diazepam-ketamine and propofol are associated with acceptable induction and recovery from anaesthesia. Propofol had inferior anaesthetic induction characteristics, but superior and quicker recovery from anaesthesia compared with diazepam-ketamine.en_ZA
dc.description.librarianam2015en_ZA
dc.description.sponsorshipUniversity of Pretoriaen_ZA
dc.description.urihttp://www.jsava.co.zaen_ZA
dc.identifier.citationFerreira, J.P., Dzikiti, T.B., Zeiler, G.E., Buck, R., Nevill, B., Gummow, B. et al., 2015, 'Anaesthetic induction and recovery characteristics of a diazepam-ketamine combination compared with propofol in dogs', Journal of the South African Veterinary Association 86(1), Art. #1258, 7 pages. http://dx.DOI.org/ 10.4102/jsava.v86i1.1258en_ZA
dc.identifier.issn1019-9128 (print)
dc.identifier.issn2224-9435 (online)
dc.identifier.other10.4102/jsava.v86i1.1258
dc.identifier.other7003908833
dc.identifier.otherN-9314-2014
dc.identifier.other27967665100
dc.identifier.otherN-8696-2014
dc.identifier.urihttp://hdl.handle.net/2263/49665
dc.language.isoenen_ZA
dc.publisherAOSIS OpenJournalsen_ZA
dc.rights© 2015. The Authors. Licensee: AOSIS Open Journals. This work is licensed under the Creative Commons Attribution License.en_ZA
dc.subjectUndesirable behaviouren_ZA
dc.subjectDogsen_ZA
dc.subjectPropofolen_ZA
dc.subjectInduction of anaesthesiaen_ZA
dc.subjectAnaesthetic inductionen_ZA
dc.subjectDiazepam-ketamineen_ZA
dc.titleAnaesthetic induction and recovery characteristics of a diazepam-ketamine combination compared with propofol in dogsen_ZA
dc.typeArticleen_ZA

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