An update on the pharmacology of anxiolytics for the anxiety, obsessive compulsive and post-traumatic stress disorders

dc.contributor.authorOuthoff, Kim
dc.contributor.emailkim.outhoff@up.ac.zaen_ZA
dc.date.accessioned2016-08-08T05:16:04Z
dc.date.available2016-08-08T05:16:04Z
dc.date.issued2016
dc.description.abstractThe anxiety disorders, obsessive compulsive disorder (OCD) and post-traumatic stress disorder (PTSD) are common and debilitating, often coexist with medical and psychiatric conditions, and usually require long-term treatment. Effective anxiolytic drugs include the selective serotonin reuptake inhibitors (SSRIs) and the serotonin and noradrenaline reuptake inhibitors (SNRIs), which are the preferred agents in primary care. Patients who fail to respond adequately to these may benefit from second-line tricyclic antidepressants or monoamine oxidase inhibitors. Alternative antidepressants include agomelatine and mirtazapine. Benzodiazepines, the anti-epileptic agent, pregabalin, and atypical antipsychotics are generally reserved for specialist use. The 5-HT1A agonist, buspirone, and the antihistamine, hydroxyzine, may also be useful, although the evidence for their efficacy covers a very narrow spectrum. This review describes the pharmacology of these anxiolytics and provides updated evidence for their use in the anxiety and related disorders.en_ZA
dc.description.departmentPharmacologyen_ZA
dc.description.librarianam2016en_ZA
dc.description.urihttp://www.sapj.co.za/index.php/sapjen_ZA
dc.identifier.citationOuthoff, K 2016, 'An update on the pharmacology of anxiolytics for the anxiety, obsessive compulsive and post-traumatic stress disorders', SA Pharmaceutical Journal, vol. 83, no. 5, pp. 24-30.en_ZA
dc.identifier.issn1015-1362
dc.identifier.urihttp://hdl.handle.net/2263/56233
dc.language.isoenen_ZA
dc.publisherMedPharm Publicationsen_ZA
dc.rights© Medpharmen_ZA
dc.subjectTreatmenten_ZA
dc.subjectObsessive compulsive disorder (OCD)en_ZA
dc.subjectPost-traumatic stress disorder (PTSD)en_ZA
dc.subjectSelective serotonin reuptake inhibitors (SSRIs)en_ZA
dc.subjectSerotonin and noradrenaline reuptake inhibitors (SNRIs)en_ZA
dc.titleAn update on the pharmacology of anxiolytics for the anxiety, obsessive compulsive and post-traumatic stress disordersen_ZA
dc.typeArticleen_ZA

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