213Bi-PSMA-617 targeted alpha-radionuclide therapy in metastatic castration-resistant prostate cancer

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Authors

Sathekge, Mike Machaba
Knoesen, Otto
Meckel, Marian
Modiselle, Moshe
Vorster, Mariza
Marx, Sebastian

Journal Title

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Volume Title

Publisher

Springer

Abstract

Prostate-specific membrane antigen radioligand therapy (PSMA-RLT) with 177Lu-PSMA holds great promise as a safe treatment option in patients with metastasized castration-resistant prostate cancer (mCRPC) with appropriate selection. This approach, together with 68Ga-PSMA PET/CT, is an excellent example of theranostic nuclear medicine. However, more structured data have recently shown that despite a marked response to PSMARLT, some patients are refractory to 177Lu-radioligand therapy. Fortunately recent studies have demonstrated that targeted α-radiation therapy with 225Ac-PSMA can significantly benefit mCRPC patients. Similarly, 213Bi-DOTATOC may be able to break the radioresistance to β-emitters while simultaneously reducing haematological toxicity in patients with diffuse red marrow infiltration by neuroendocrine tumour.

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Keywords

177Lu-PSMA, Treatment, Patients, Prostate-specific membrane antigen radioligand therapy (PSMA-RLT), Metastasized castration-resistant prostate cancer (mCRPC)

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Citation

Sathekge, M., Knoesen, O., Meckel, M. et al. 213Bi-PSMA-617 targeted alpha-radionuclide therapy in metastatic castration-resistant prostate cancer. European Journal of Nuclear Medicine and Molecular Imaging (2017) 44: 1099-1100. https://doi.org/10.1007/s00259-017-3657-9.