Accelerated induction of etorphine immobilization in blue wildebeest (Connochaetes taurinus) through the addition of hyaluronidase

dc.contributor.authorDittberner, Mark
dc.contributor.authorVenter, Leon
dc.contributor.authorNaidoo, Vinny
dc.contributor.emailvinny.naidoo@up.ac.zaen_ZA
dc.date.accessioned2016-02-12T07:52:48Z
dc.date.issued2015-03
dc.description.abstractOBJECTIVE : To study the effects of the addition of hyaluronidase (HA) to an etorphine/azaperone drug combination on induction times of immobilization. STUDY DESIGN : Experimental part-randomized 'blinded' cross-over study. ANIMALS : Eight wild managed blue wildebeest (Connochaetes taurinus). METHODS : Animals were immobilized, on separate occasions separated by two weeks, with one of four treatments. Treatments were; 'Control drugs (CD), etorphine 0.01 mg kg(-1) + azaperone at 0.1 mg kg(-1) ; treatment 1 CD + 5000IU HA; treatment 2 CD + 7500 IU HA; and treatment 3 etorphine 0.007 mg kg(-1) + azaperone at 0.07 mg kg(-1) + 7500 IU HA. Times to first effect and to immobilization (from darting to possible to approach and blindfold) were measured. anova was used to compare treatments. Results are given in means ± SD (range). RESULTS : For control, and treatments 1-3 respectively, times (in minutes) to first effect were 1.58 ± 0.42 (1.02-2.10), 1.64 ± 0.42 (0.95-2.17), 1.12 ± 0.24 (0.80-1.48) and 1.60 ± 0.21 (1.13-1.88) and to immobilization were 5.38 ± 1.53 (3.82-8.07), 3.80 ± 1.14 (2.02-5.50), 3.51 ± 1.08 (2.28-5.52) and 4.46 ± 0.67 (3.30-5.40). Compared to control, time to first effect for treatment 2 was significantly shorter. Time to immobilization was significantly quicker in all three treatments containing HA than that for control. CONCLUSION AND CLINICAL RELEVANCE : Hyaluronidase can reduce the time to immobilization when used in the immobilizing dart, and might be usefully incorporated into etorphine combinations for darting wildlife.en_ZA
dc.description.embargo2016-03-31
dc.description.librarianhb2015en_ZA
dc.description.sponsorshipUniversity of Pretoria and the South African Veterinary Foundation.en_ZA
dc.description.urihttp://onlinelibrary.wiley.com/journal/10.1111/(ISSN)1467-2995en_ZA
dc.identifier.citationDittberner, MJ, Venter, L & Naidoo, V 2015, 'Accelerated induction of etorphine immobilization in blue wildebeest (Connochaetes taurinus) through the addition of hyaluronidase', Veterinary Anaesthesia and Analgesia, vol. 42, no. 3, pp. 173-177.en_ZA
dc.identifier.issn1467-2987 (print)
dc.identifier.issn1467-2995 (online)
dc.identifier.other10.1111/vaa.12188
dc.identifier.urihttp://hdl.handle.net/2263/51332
dc.language.isoenen_ZA
dc.publisherWileyen_ZA
dc.rights© 2014 Association of Veterinary Anaesthetists and the American College of Veterinary Anesthesia and Analgesia. Wiley. This is the pre-peer reviewed version of the following article : Accelerated induction of etorphine immobilization in blue wildebeest (Connochaetes taurinus) through the addition of hyaluronidase, Veterinary Anaesthesia and Analgesia, vol. 42, no. 3, pp. 173-177, 2015. doi : 10.1111/vaa.12188. The definite version is available at : http://onlinelibrary.wiley.comjournal/10.1111/(ISSN)1467-2995.en_ZA
dc.subjectAzaperoneen_ZA
dc.subjectEtorphineen_ZA
dc.subjectImmobilisation timeen_ZA
dc.subjectHyaluronidaseen_ZA
dc.subjectBlue wildebeest (Connochaetes taurinus)en_ZA
dc.subjectConnochaetes taurinus
dc.titleAccelerated induction of etorphine immobilization in blue wildebeest (Connochaetes taurinus) through the addition of hyaluronidaseen_ZA
dc.typePostprint Articleen_ZA

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