Thiol modified mycolic acids

dc.contributor.authorBalogun, Mohammed Olusegun
dc.contributor.authorHuws, Enlli
dc.contributor.authorSirhan, Muthana M.
dc.contributor.authorSaleh, Ahmed D.
dc.contributor.authorAl Dulayymi, Juma’a R.
dc.contributor.authorPilcher, Lynne A.
dc.contributor.authorVerschoor, Jan Adrianus
dc.contributor.authorBaird, Mark S.
dc.date.accessioned2017-02-28T11:17:18Z
dc.date.available2017-02-28T11:17:18Z
dc.date.issued2013-07
dc.description.abstractPatient serum antibodies to mycolic acids have the potential to be surrogate markers of active tuberculosis (TB) when they can be distinguished from the ubiquitously present cross-reactive antibodies to cholesterol. Mycolic acids are known to interact more strongly with antibodies present in the serum of patients with active TB than in patients with latent TB or no TB. Examples of single stereoisomers of mycolic acids with chain lengths corresponding to major homologues of those present in Mycobacterium tuberculosis have now been synthesised with a sulfur substituent on the terminal position of the -chain; initial studies have established that one of these binds to a gold electrode surface, offering the potential to develop second generation sensors for diagnostic patient antibody detection.en_ZA
dc.description.departmentBiochemistryen_ZA
dc.description.departmentChemistryen_ZA
dc.description.librarianhb2017en_ZA
dc.description.sponsorshipMMS and ADS wish to acknowledge support from the Government of Iraq through the award of PhD studentships.en_ZA
dc.description.urihttp://www.elsevier.com/locate/chemphyslipen_ZA
dc.identifier.citationBalogun, MO, Huws, EH, Sirhan, MM, Saleh, AD, Al Dulayymi, JR, Pilcher, L, Verschoor, JA & Baird, MS 2013, 'Thiol modified mycolic acids', Chemistry and Physics of Lipids, vol. 172-173, pp. 40-55.en_ZA
dc.identifier.issn0009-3084 (print)
dc.identifier.issn1873-2941 (online)
dc.identifier.other10.1016/j.chemphyslip.2013.03.004
dc.identifier.urihttp://hdl.handle.net/2263/59198
dc.language.isoenen_ZA
dc.publisherElsevieren_ZA
dc.rights© 2013 Elsevier Ireland Ltd. All rights reserved. Notice : this is the author’s version of a work that was accepted for publication in Chemistry and Physics of Lipids. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. A definitive version was subsequently published in Chemistry and Physics of Lipids, vol. 172-173, pp. 40-55, 2013. doi : 10.1016/j.chemphyslip.2013.03.004.en_ZA
dc.subjectMycolic acidsen_ZA
dc.subjectThiolateden_ZA
dc.subjectGold surfacesen_ZA
dc.subjectCyclic voltammetryen_ZA
dc.subjectTuberculosis (TB)en_ZA
dc.titleThiol modified mycolic acidsen_ZA
dc.typePostprint Articleen_ZA

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