Pneumonia as a systemic illness

dc.contributor.authorFeldman, Charles
dc.contributor.authorAnderson, Ronald
dc.date.accessioned2019-03-25T06:58:50Z
dc.date.issued2018-05
dc.description.abstractPURPOSE OF REVIEW : The manuscript reviews the recent literature describing the occurrence, risk factors, recognition and treatment of sepsis, respiratory failure, and multiple organ dysfunction in patients with community-acquired pneumonia (CAP). RECENT FINDINGS : CAP may present with varying degrees of disease severity ranging from an almost asymptomatic infection to a fulminant systemic disease with both respiratory failure and multiple organ dysfunction. Severe sepsis occurs early in the course of the infection in more than 30% of cases. It may involve several organ systems and is associated with the severity and mortality of CAP. A number of factors exist, which may promote the transition of CAP from a local to a systemic disease, particularly immunosuppression and poorly controlled inflammatory responses, which promote extrapulmonary dissemination of the causative pathogens. Although CAP may be associated with complications involving most organ systems, much recent research has focused attention on cardiac complications, particularly those associated with pneumococcal infections. Biomarkers as a strategy for discriminating between invasive and noninvasive CAP have been comprehensively studied. A number of treatment strategies using antibiotics and various adjunctive therapies have been studied in severe CAP. SUMMARY : Recent research highlights the fact that CAP is frequently a systemic illness.en_ZA
dc.description.departmentImmunologyen_ZA
dc.description.embargo2019-05-01
dc.description.librarianhj2019en_ZA
dc.description.sponsorshipC.F. is supported by the National Research Foundation of South Africa.en_ZA
dc.description.urihttp://journals.lww.com/co-pulmonarymedicineen_ZA
dc.identifier.citationFeldman, C. & Anderson, R. 2018, 'Pneumonia as a systemic illness', Current Opinion in Pulmonary Medicine, vol. 24, no. 3, pp. 237-243.en_ZA
dc.identifier.issn1070-5287 (print)
dc.identifier.issn1531-6971 (online)
dc.identifier.other10.1097/MCP.0000000000000466
dc.identifier.urihttp://hdl.handle.net/2263/68692
dc.language.isoenen_ZA
dc.publisherLippincott Williams and Wilkinsen_ZA
dc.rights© Copyright 2018 Wolters Kluwer Health, Inc. All rights reserved.. This is a non-final version of an article published in final form in Current Opinion in Pulmonary Medicine, vol. 24, no. 3, pp. 237-243, 2018. doi : 10.1097/MCP.0000000000000466.en_ZA
dc.subjectCommunity-acquired pneumonia (CAP)en_ZA
dc.subjectOccurrenceen_ZA
dc.subjectPatientsen_ZA
dc.subjectRisk factorsen_ZA
dc.subjectRecognition of sepsisen_ZA
dc.subjectTreatment of sepsisen_ZA
dc.subjectRespiratory failureen_ZA
dc.subjectMultiple organ dysfunctionen_ZA
dc.subjectSystemic illnessen_ZA
dc.titlePneumonia as a systemic illnessen_ZA
dc.typePostprint Articleen_ZA

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