A prospective investigation of tumor hypoxia imaging with 68Ga-nitroimidazole PET/CT in patients with carcinoma of the cervix uteri and comparison with 18F-FDG PET/CT : correlation with immunohistochemistry

dc.contributor.authorMokoala, Kgomotso M.G.
dc.contributor.authorLawal, Ismaheel Opeyemi
dc.contributor.authorMaserumule, Letjie C.
dc.contributor.authorHlongwa, Khanyisile N.
dc.contributor.authorNdlovu, Honest
dc.contributor.authorReed, Janet D.
dc.contributor.authorBida, Nndweleni Meshack
dc.contributor.authorMaes, Alex
dc.contributor.authorVan de Wiele, Christophe
dc.contributor.authorMahapane, Johncy
dc.contributor.authorDavis, Cindy
dc.contributor.authorJeong, Jae Min
dc.contributor.authorPopoola, Gbenga O.
dc.contributor.authorVorster, Mariza
dc.contributor.authorSathekge, Mike Machaba
dc.contributor.emailmike.sathekge@up.ac.zaen_US
dc.date.accessioned2022-09-02T05:24:30Z
dc.date.available2022-09-02T05:24:30Z
dc.date.issued2021-02-12
dc.description.abstractHypoxia in cervical cancer has been associated with a poor prognosis. Over the years 68Ga labelled nitroimidazoles have been studied and have shown improved kinetics. We present our initial experience of hypoxia Positron Emission Tomography (PET) imaging in cervical cancer with 68Ga-Nitroimidazole derivative and the correlation with 18F-FDG PET/CT and immunohistochemistry. Twenty women with cervical cancer underwent both 18F-FDG and 68Ga-Nitroimidazole PET/CT imaging. Dual-point imaging was performed for 68Ga-Nitroimidazole PET. Immunohistochemical analysis was performed with hypoxia inducible factor-1 (HIF-1 ). We documented SUVmax, SUVmean of the primary lesions as well as tumor to muscle ratio (TMR), tumor to blood (TBR), metabolic tumor volume (MTV) and hypoxic tumor volume (HTV). There was no significant difference in the uptake of 68Ga-Nitroimidazole between early and delayed imaging. Twelve patients had uptake on 68Ga-Nitroimidazole PET. Ten patients demonstrated varying intensities of HIF-1 expression and six of these also had uptake on 68Ga-Nitroimidazole PET. We found a strong negative correlation between HTV and immunohistochemical staining (r = 0.660; p = 0.019). There was no correlation between uptake on PET imaging and immunohistochemical analysis with HIF-1 . Two-thirds of the patients demonstrated hypoxia on 68Ga-Nitroimidazole PET imaging.en_US
dc.description.departmentNuclear Medicineen_US
dc.description.librarianam2022en_US
dc.description.urihttps://www.mdpi.com/journal/jcmen_US
dc.identifier.citationMokoala, K.M.G.; Lawal, I.O.; Maserumule, L.C.; Hlongwa, K.N.; Ndlovu, H.; Reed, J.; Bida, M.; Maes, A.; van deWiele, C.; Mahapane, J.; et al. A Prospective Investigation of Tumor Hypoxia Imaging with 68Ga-Nitroimidazole PET/CT in Patients with Carcinoma of the Cervix Uteri and Comparison with 18F-FDG PET/CT: Correlation with Immunohistochemistry. Journal of Clinical Medicine 2022, 11, 962. https://DOI.org/10.3390/jcm11040962.en_US
dc.identifier.issn2077-0383 (online)
dc.identifier.other10.3390/jcm11040962
dc.identifier.urihttps://repository.up.ac.za/handle/2263/87034
dc.language.isoenen_US
dc.publisherMDPIen_US
dc.rights© 2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license.en_US
dc.subjectCervical canceren_US
dc.subjectHypoxiaen_US
dc.subject68Ga-Nitroimidazoleen_US
dc.subject18F-FDGen_US
dc.subjectImmunohistochemistryen_US
dc.subjectPositron emission tomography (PET)en_US
dc.subjectHypoxia inducible factor-1 (HIF-1)en_US
dc.subjectHypoxic tumor volume (HTV)en_US
dc.subjectTumor to muscle ratio (TMR)en_US
dc.subjectTumor to blood (TBR)en_US
dc.subjectMetabolic tumor volume (MTV)en_US
dc.titleA prospective investigation of tumor hypoxia imaging with 68Ga-nitroimidazole PET/CT in patients with carcinoma of the cervix uteri and comparison with 18F-FDG PET/CT : correlation with immunohistochemistryen_US
dc.typeArticleen_US

Files

Original bundle

Now showing 1 - 1 of 1
Loading...
Thumbnail Image
Name:
Mokoala_Prospective_2021.pdf
Size:
1.61 MB
Format:
Adobe Portable Document Format
Description:
Article

License bundle

Now showing 1 - 1 of 1
Loading...
Thumbnail Image
Name:
license.txt
Size:
1.75 KB
Format:
Item-specific license agreed upon to submission
Description: