First ancient mitochondrial human genome from a prepastoralist Southern African

dc.contributor.authorMorris, Alan G.
dc.contributor.authorHeinze, Anja
dc.contributor.authorChan, Eva K.F.
dc.contributor.authorSmith, Andrew B.
dc.contributor.authorHayes, Vanessa M.
dc.date.accessioned2015-11-09T07:38:03Z
dc.date.available2015-11-09T07:38:03Z
dc.date.issued2014-09
dc.description.abstractThe oldest contemporary human mitochondrial lineages arose in Africa. The earliest divergent extant maternal offshoot, namely haplogroup L0d, is represented by click-­‐speaking forager peoples of Southern Africa. Broadly defined as Khoesan, contemporary Khoesan are today largely restricted to the semi-­‐ desert regions of Namibia and Botswana, while archeological, historical and genetic evidence promotes a once broader southerly dispersal of click-­‐speaking peoples including southward migrating pastoralists and indigenous marine-­‐foragers. Today extinct, no genetic data has been recovered from the indigenous peoples that once sustained life along the southern coastal waters of Africa pre-­‐pastoral arrival. In this study we generate a complete mitochondrial genome from a 2,330 year old male skeleton, confirmed via osteological and archeological analysis as practicing a marine-­‐based forager existence. The ancient mtDNA represents a new L0d2c lineage (L0d2c1c) that is today, unlike its Khoe-­‐language based sister-­‐ clades (L0d2c1a and L0d2c1b) most closely related to contemporary indigenous San-­‐speakers (specifically Ju). Providing the first genomic evidence that pre-­‐pastoral Southern African marine foragers carried the earliest diverged maternal modern human lineages, this study emphasizes the significance of Southern African archeological remains in defining early modern human origins.en_ZA
dc.description.librarianhb2015en_ZA
dc.description.sponsorshipJ. Craig Venter Family Foundation, La Jolla, CA, U.S.A. and the Max Planck Society (within the laboratory of Svante Pääbo).en_ZA
dc.description.urihttp://gbe.oxfordjournals.orgen_ZA
dc.identifier.citationMorris, AG, Heinze, A, Chan, EKF, Smith, AB & Hayes, VM 2014, 'First ancient mitochondrial human genome from a prepastoralist Southern African', Genome Biology and Evolution (Open Access), vol. 6, no. 10, pp. 2647-2653.en_ZA
dc.identifier.issn1759-6653 (online)
dc.identifier.other10.1093/gbe/evu202
dc.identifier.urihttp://hdl.handle.net/2263/50382
dc.language.isoenen_ZA
dc.publisherOxford University Press (open Access)en_ZA
dc.rights© The Author(s) 2014. Published by Oxford University Press on behalf of the Society for Molecular Biology and Evolution.This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/).en_ZA
dc.subjectMitochondrial genomeen_ZA
dc.subjectKhoesanen_ZA
dc.subjectSouthern Africaen_ZA
dc.subjectMarine foragersen_ZA
dc.subjectArcheological skeletonsen_ZA
dc.subjectDeoxyribonucleic acid (DNA)en_ZA
dc.subjectAncient DNAen_ZA
dc.titleFirst ancient mitochondrial human genome from a prepastoralist Southern Africanen_ZA
dc.typeArticleen_ZA

Files

Original bundle

Now showing 1 - 1 of 1
Loading...
Thumbnail Image
Name:
Morris_First_2014.pdf
Size:
626.38 KB
Format:
Adobe Portable Document Format
Description:
Article

License bundle

Now showing 1 - 1 of 1
Loading...
Thumbnail Image
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed upon to submission
Description: