Increased CSF aquaporin-4, and interleukin-6 levels in dogs with idiopathic communicating internal hydrocephalus and a decrease after ventriculo-peritoneal shunting

dc.contributor.authorSchmidt, Martin J.
dc.contributor.authorRummel, Christoph
dc.contributor.authorHauer, Jessica
dc.contributor.authorKolecka, Malgorzata
dc.contributor.authorOndreka, Nele
dc.contributor.authorMcClure, Vanessa
dc.contributor.authorRoth, Joachim
dc.date.accessioned2016-07-18T08:37:00Z
dc.date.available2016-07-18T08:37:00Z
dc.date.issued2016-06-29
dc.description.abstractBACKGROUND : Studies in animal models, in which internal hydrocephalus has been induced by obstructing the cerebrospinal fluid pathways, have documented an up-regulation of the concentrations of aquaporin-4 (AQP4) in the brain. In this study, the concentrations of aquaporin-1 (AQP1), AQP1, AQP4 and interleukin-6 (IL-6) were determined in the CSF of dogs with idiopathic communicating hydrocephalus before and after the reduction of intraventricular volume following ventriculo-peritoneal shunt (VP-shunt) treatment. RESULTS : The concentrations of AQP4 and IL-6 were increased in the cerebrospinal fluid of dogs with hydrocephalus compared to controls. Both parameters significantly decreased after surgical treatment, accompanied by decrease of ventricular size and the clinical recovery of the dogs. AQP1 was not detectable in CSF. CONCLUSIONS : Brain AQP4 up-regulation might be a compensatory response in dogs with hydrocephalus. Future determination of AQP4 at the mRNA and protein level in brain tissue is warranted to substantiate this hypothesis.en_ZA
dc.description.departmentCompanion Animal Clinical Studiesen_ZA
dc.description.librarianam2016en_ZA
dc.description.urihttp://www.sherpa.ac.uk/romeo/issn/2045-8118/en_ZA
dc.identifier.citationSchmidt, M, Rummel, C, Hauer, J, Kolecka, M, Ondreka, N, Vanessa McClure, V & Roth, J 2016, 'Increased CSF aquaporin-4, and interleukin-6 levels in dogs with idiopathic communicating internal hydrocephalus and a decrease after ventriculo-peritoneal shunting', Fluids and Barriers of the CNS, vol. 13, art. #12, pp. 1-11.en_ZA
dc.identifier.issn2045-8118 (print)
dc.identifier.other10.1186/s12987-016-0034-1
dc.identifier.urihttp://hdl.handle.net/2263/55853
dc.language.isoenen_ZA
dc.publisherBioMed Centralen_ZA
dc.rights© 2016 The Author(s). This article is distributed under the terms of the Creative Commons Attribution 4.0 International License.en_ZA
dc.subjectAquaporinen_ZA
dc.subjectCommunicating hydrocephalusen_ZA
dc.subjectDogsen_ZA
dc.subjectInterleukin-6en_ZA
dc.subjectAquaporin-4 (AQP4)en_ZA
dc.titleIncreased CSF aquaporin-4, and interleukin-6 levels in dogs with idiopathic communicating internal hydrocephalus and a decrease after ventriculo-peritoneal shuntingen_ZA
dc.typeArticleen_ZA

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