The effect of positive end-expiratory pressure on pulse pressure variation

dc.contributor.authorSmith, Francois Jacobus
dc.contributor.authorGeyser, M.M. (Mimi)
dc.contributor.authorSchreuder, I.
dc.contributor.authorBecker, Piet J.
dc.contributor.emailfj.smith@up.ac.zaen_US
dc.date.accessioned2013-04-25T07:32:00Z
dc.date.available2013-04-25T07:32:00Z
dc.date.issued2012-06-19
dc.description.abstractOBJECTIVES: To determine the effect of different levels of positive end-expiratory pressure (PEEP) on pulse pressure variation (PPV). DESIGN: An observational study. SETTING: Operating theatres of a tertiary training hospital. SUBJECTS: Ventilated patients who required intra-arterial blood pressure monitoring. OOUTCOME MEASURES: PPV during different levels of PEEP. METHOD: Patients were anaesthetised by means of a standard technique and ventilated with a tidal volume of 9 ml/kg ideal body mass. The PPV was calculated at PEEP levels of 2, 5, 8 and 10 cmH2O. PPV was compared at the various PEEP levels. RESULTS: PPV at a PEEP of 8 cmH2O and 10 cmH2O was significantly larger than that at 2 cmH2O (p-value < 0.001). PPV at a PEEP of 10 cmH2O was significantly larger than that at 8 cmH2O (p-value < 0.001). PPV at a PEEP of 8 cmH2O was larger than that at 5 cmH2O (p-value = 0.002). PPV at a PEEP of 2 and 5 cmH2O did not differ significantly (p-value = 0.194). CONCLUSION: We have demonstrated that, in patients with normal lungs, PEEP has a significant influence on PPV. PPV may be overestimated if PEEP ≥ 8 cmH2O is applied in patients who are ventilated with a tidal volume of 9 ml/kg. It is recommended that in patients with healthy lungs PPV should be measured at a standardised PEEP of ≤ 5 cmH2O.en_US
dc.description.librarianam2013en_US
dc.description.librarianay2013
dc.description.urihttp://www.sajaa.co.za/index.php/sajaaen_US
dc.format.extent6 p.en_US
dc.format.mediumPDFen_US
dc.identifier.citationSmith, FJ, Geyser, M, Schreuder, I & Becker, PJ 2012, 'The effect of positive end-expiratory pressure on pulse pressure variation', Southern African Journal of Anaesthesia and Analgesia, vol. 18, no. 6, pp. 333-338.en_US
dc.identifier.issn1027-9148
dc.identifier.urihttp://hdl.handle.net/2263/21378
dc.language.isoenen_US
dc.publisherOpenJournals Publishingen_US
dc.rights© SASAen_US
dc.subjectBlood volumeen_US
dc.subjectMonitoringen_US
dc.subjectPulse pressureen_US
dc.subjectBlood pressure determinationen_US
dc.subjectPositive-pressure respirationen_US
dc.subjectPositive end-expiratory pressureen_US
dc.subject.lcshBlood pressure -- Measurementen
dc.subject.lcshAnesthesiology -- Research -- South Africaen
dc.subject.lcshVentilation (Physiology)en
dc.titleThe effect of positive end-expiratory pressure on pulse pressure variationen_US
dc.typeArticleen_US

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