Clinical presentation and pathology of suspected vector transmitted African horse sickness in South African domestic dogs from 2006 to 2017

dc.contributor.authorO'Dell, Nicolize
dc.contributor.authorArnot, L.F. (Luke)
dc.contributor.authorJanisch, Chris Eric
dc.contributor.authorSteyl, Johan Christian Abraham
dc.contributor.emailnicolize.odell@up.ac.zaen_ZA
dc.date.accessioned2018-11-27T05:11:45Z
dc.date.available2018-11-27T05:11:45Z
dc.date.issued2018-06
dc.description.abstractAfrican horse sickness (AHS) is a fatal vector transmitted viral disease of horses caused by the African horse sickness virus (AHSV). This disease is characterised by circulatory and respiratory failure, resulting from vascular endothelial injury affecting many organs. The susceptibility of dogs to AHS has been demonstrated in the past following experimental infection through consumption of infected horse meat. Thirty three clinical cases of AHS in dogs (cAHS) have been documented, without a history of ingesting infected horse meat, over a period of 12 years. The clinical cases included in this study presented with a history of acute respiratory distress syndrome or sudden death. The macroscopic and histological changes were mostly characterised by acute interstitial pneumonia, serofibrinous pleuritis and mediastinal oedema. Confirmation of cAHS was obtained by AHS specific NS4 antibody immunohistochemistry and/or AHSV specific duplex real time RT-quantitative PCR. Here, we document the clinical and postmortem diagnostic features of confirmed cAHS cases with no history of ingestion of AHS infected horse meat.en_ZA
dc.description.departmentParaclinical Sciencesen_ZA
dc.description.departmentProduction Animal Studiesen_ZA
dc.description.librarianhj2018en_ZA
dc.description.urihttp://veterinaryrecord.bmj.comen_ZA
dc.identifier.citationO'Dell, N., Arnot, L., Janisch, C.E. & Steyl, J.C.A. 2018, 'Clinical presentation and pathology of suspected vector transmitted African horse sickness in South African domestic dogs from 2006 to 2017', Veterinary Record, vol. 182, no. 25, pp. 1-5en_ZA
dc.identifier.issn0042-4900 (print)
dc.identifier.issn2042-7670 (online)
dc.identifier.other10.1136/vr.104611
dc.identifier.urihttp://hdl.handle.net/2263/67329
dc.language.isoenen_ZA
dc.publisherBMJ Publishing Groupen_ZA
dc.rights© 2018 by the BMJ Publishing Group Ltd. All rights reserved.en_ZA
dc.subjectAfrican horse sickness (AHS)en_ZA
dc.subjectAfrican horse sickness virus (AHSV)en_ZA
dc.subjectDogs (Canis familiaris)en_ZA
dc.subjectCanineen_ZA
dc.subjectDiagnosisen_ZA
dc.subjectPathologyen_ZA
dc.subjectNonstructural protein 4 antibodyen_ZA
dc.subjectProtein antibodyen_ZA
dc.subjectUnclassified drugen_ZA
dc.subjectAcute respiratory distress syndromeen_ZA
dc.subjectAnimal tissueen_ZA
dc.subjectAntibody specificityen_ZA
dc.subjectDomestic animalen_ZA
dc.titleClinical presentation and pathology of suspected vector transmitted African horse sickness in South African domestic dogs from 2006 to 2017en_ZA
dc.typePostprint Articleen_ZA

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