Antimicrobial drug administration and antimicrobial resistance of Salmonella isolates originating from the broiler production value chain in Nigeria

dc.contributor.authorOloso, Nurudeen Olalekan
dc.contributor.authorAdeyemo, Ismail Adewuyi
dc.contributor.authorVan Heerden, Henriette
dc.contributor.authorOlubunmi Gabriel Fasanmi
dc.contributor.authorFasina, Folorunso Oludayo
dc.contributor.emailvanheerden@up.ac.zaen_ZA
dc.date.accessioned2020-07-15T06:13:17Z
dc.date.available2020-07-15T06:13:17Z
dc.date.issued2019-06-06
dc.description.abstractSalmonella is among the pathogens on the high global priority lists for monitoring for studies on the discovery of new antimicrobials and understanding of how antimicrobial resistance (AMR) develops. AMR in connection with antibiotic usage patterns has been considered as a strong factor and contributor to the AMR pool. The purposes of use, pattern of antimicrobial drug administration, as well as the prevalence of AMR in Salmonella originating from the Nigeria broiler production value chain (NBPVC) was explored. A well-structured questionnaire on antimicrobial usage (n = 181) was used for sampling that focused on 21 antimicrobials from 151 locations. Simultaneously, AMR testing for 18 commonly used antimicrobials on Salmonella in humans was also carried out. Antimicrobial resistance Salmonella spp. were isolated in 23% of the samples (261 of 1135 samples from the broiler input, products, and the environment) using modified ISO 6579 and invA PCR protocols. Over 80% of the antimicrobials used in the NBPVC were administered without a veterinarian prescription. Prevalence of antimicrobial administration without prescription were as follows: live-bird-market (100%), hatchery (86.7%), grow-out-farm (75%), and breeder (66.7%). Widespread prophylactic and metaphylactic use of antimicrobials were recorded with the highest use seen for enrofloxacin (63% and 24%), tetracycline (58% and 33%), and erythromycin (50% and 17%). Antimicrobial resistance was highest for flumequine (100%), penicillin (95%), and perfloxacin (89%). High levels of use without laboratory support of a newer generation of a class of antibiotics suspected to confer high resistance on older generations of the same class (quinolones) was observed.en_ZA
dc.description.departmentProduction Animal Studiesen_ZA
dc.description.departmentVeterinary Tropical Diseasesen_ZA
dc.description.librarianam2020en_ZA
dc.description.sponsorshipThis research was partially funded by the University of Pretoria Doctoral Research Support Scholarship to the first author in the 2016, 2017, and 2018 funding years.en_ZA
dc.description.sponsorshipThe lead author (N.O.O.) acknowledges the contribution of Engineer Saheed OLOSO and Dr. Munirudeen for their financial and moral contributions; We thank the members of the Poultry Association of Nigeria through the Oyo State chapter and the Nigeria Veterinary Medical Association, Oyo State Branch, Nigeria.en_ZA
dc.description.sponsorshipThe University of Pretoria Doctoral Research Support Scholarship, Engineer Saheed OLOSO and Dr. Munirudeen.en_ZA
dc.description.urihttps://www.mdpi.com/journal/antibioticsen_ZA
dc.identifier.citationOloso, N.O., Adeyemo, I.A., Heerden, H.V. et al. 2019, 'Antimicrobial drug administration and antimicrobial resistance of salmonella isolates originating from the broiler production value chain in nigeria', Antibiotics, vol. 8, no. 75, pp. 1-13.en_ZA
dc.identifier.issn2079-6382 (online)
dc.identifier.other10.3390/antibiotics8020075
dc.identifier.urihttp://hdl.handle.net/2263/75227
dc.language.isoenen_ZA
dc.publisherMDPIen_ZA
dc.rights© 2019 by the authors. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license.en_ZA
dc.subjectFood animal residueen_ZA
dc.subjectAntimicrobial usageen_ZA
dc.subjectAntimicrobial stewardship (AMS)en_ZA
dc.subjectEnvironmenten_ZA
dc.subjectLive bird marketen_ZA
dc.subjectBreeder broileren_ZA
dc.subjectHatcheryen_ZA
dc.subjectNigeria broiler production value chain (NBPVC)en_ZA
dc.subjectAntimicrobial resistance (AMR)en_ZA
dc.subjectPolymerase chain reaction (PCR)en_ZA
dc.titleAntimicrobial drug administration and antimicrobial resistance of Salmonella isolates originating from the broiler production value chain in Nigeriaen_ZA
dc.typeArticleen_ZA

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