The role of neurokinin B signalling in reproductive neuroendocrinology

dc.contributor.authorGrachev, Pasha
dc.contributor.authorMillar, Robert P.
dc.contributor.authorO’Byrne, Kevin T.
dc.date.accessioned2015-09-08T10:11:12Z
dc.date.available2015-09-08T10:11:12Z
dc.date.issued2014-12
dc.description.abstractThe KNDy neuropeptides, kisspeptin, neurokinin B (NKB) and dynorphin A (Dyn), have been implicated in regulating pulsatile luteinising hormone (LH) secretion. Studies of the interactions between KNDy signalling systems, however, are currently few. Although the stimulatory effect of kisspeptin and the inhibitory effect of Dyn on the gonadotropin-releasing hormone pulse generator are widely accepted, the effects of NKB in rodents are variable and sometimes controversial. Literature describing increased LH secretion in response to NKB receptor agonism predominates and is in line with human physiology, as well as the pathophysiology of pubertal failure associated with disruption of NKB signalling. However, the robust suppression of the LH pulse, induced by the same treatment under hypoestrogenic conditions, may hold clues as to the mechanisms of reproductive inhibition under pathological conditions. This review discusses the recent evidence for this paradox and outlines a revised working model incorporating the mechanisms by which KNDy neuropeptides modulate the reproductive axis.en_ZA
dc.description.librarianhb2015en_ZA
dc.description.sponsorshipMedical Research Council Centenary Early Career Awarden_ZA
dc.description.urihttp://www.karger.com/Journal/Home/223855en_ZA
dc.identifier.citationGrachev, P, Millar, RP & O'Byrne, KT 2014, 'The role of neurokinin B signalling in reproductive neuroendocrinology', Neuroendocrinology, vol. 99, no. 1, p. 7-17.en_ZA
dc.identifier.issn0028-3835 (print)
dc.identifier.issn1423-0194 (online)
dc.identifier.other10.1159/000357734
dc.identifier.urihttp://hdl.handle.net/2263/49743
dc.language.isoenen_ZA
dc.publisherKargeren_ZA
dc.rights© 2014 S. Karger AG, Baselen_ZA
dc.subjectKisspeptinen_ZA
dc.subjectNeurokinin B (NKB)en_ZA
dc.subjectDynorphin A (Dyn)en_ZA
dc.subjectLuteinising hormone (LH)en_ZA
dc.subjectGonadotropin-releasing hormone (GnRH)en_ZA
dc.titleThe role of neurokinin B signalling in reproductive neuroendocrinologyen_ZA
dc.typePostprint Articleen_ZA

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