MADIBA : A web server toolkit for biological interpretation of Plasmodium and plant gene clusters

dc.contributor.authorLaw, Philip J.
dc.contributor.authorClaudel-Renard, Clotilde
dc.contributor.authorJoubert, Fourie
dc.contributor.authorLouw, Abraham Izak
dc.contributor.authorBerger, David Kenneth
dc.date.accessioned2009-02-17T11:50:42Z
dc.date.available2009-02-17T11:50:42Z
dc.date.issued2008
dc.description.abstractBACKGROUND: Microarray technology makes it possible to identify changes in gene expression of an organism, under various conditions. Data mining is thus essential for deducing significant biological information such as the identification of new biological mechanisms or putative drug targets. While many algorithms and software have been developed for analysing gene expression, the extraction of relevant information from experimental data is still a substantial challenge, requiring significant time and skill. DESCRIPTION: MADIBA (MicroArray Data Interface for Biological Annotation) facilitates the assignment of biological meaning to gene expression clusters by automating the post-processing stage. A relational database has been designed to store the data from gene to pathway for Plasmodium, rice and Arabidopsis. Tools within the web interface allow rapid analyses for the identification of the Gene Ontology terms relevant to each cluster; visualising the metabolic pathways where the genes are implicated, their genomic localisations, putative common transcriptional regulatory elements in the upstream sequences, and an analysis specific to the organism being studied. CONCLUSION: MADIBA is an integrated, online tool that will assist researchers in interpreting their results and understand the meaning of the co-expression of a cluster of genes. Functionality of MADIBA was validated by analysing a number of gene clusters from several published experiments – expression profiling of the Plasmodium life cycle, and salt stress treatments of Arabidopsis and rice. In most of the cases, the same conclusions found by the authors were quickly and easily obtained after analysing the gene clusters with MADIBA.en_US
dc.identifier.citationLaw, PJ, Claudel-Renard, C, Joubert, F, Louw, A I & Berger, DK 2008, ‘MADIBA : A web server toolkit for biological interpretation of Plasmodium and plant gene clusters’, BMC Genomics, vol. 9, no. 105, pp. 1-11. [http:// www.biomedcentral.com/bmcbioinformatics/]en_US
dc.identifier.issn1471-2164
dc.identifier.other10.1186/1471-2164-9-105
dc.identifier.urihttp://hdl.handle.net/2263/8926
dc.language.isoenen_US
dc.publisherBioMed Centralen_US
dc.rightsCopyright belongs to the authorsen_US
dc.subjectPlasmodiumen_US
dc.subjectInterpretationen_US
dc.subjectMADIBA (MicroArray Data Interface for Biological Annotation)en
dc.subject.lcshBiochemistry -- Computer programsen
dc.subject.lcshDNA microarrays -- Computer programsen
dc.titleMADIBA : A web server toolkit for biological interpretation of Plasmodium and plant gene clustersen_US
dc.typeArticleen_US

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