Human leukocyte antigen (HLA) diversity and clinical applications in South Africa

dc.contributor.authorMellet, Juanita
dc.contributor.authorTshabalala, Mqondisi
dc.contributor.authorAgbedare, O.
dc.contributor.authorMeyer, Pieter Willem Adriaan
dc.contributor.authorGray, C.M.
dc.contributor.authorPepper, Michael Sean
dc.date.accessioned2020-05-27T09:39:22Z
dc.date.available2020-05-27T09:39:22Z
dc.date.issued2019-09
dc.description.abstractThe major histocompatibility complex, known as the human leukocyte antigen (HLA) complex in humans, forms an integral component of adaptive T cell immunity by presenting self and non-self peptides to the T cell receptor, thereby allowing clonal expansion of responding peptide-specific CD4+ and CD8+ T cells. HLA likewise forms an integral part of the innate immune response through the binding of killercell immunoglobulin-like receptor (KIR) molecules, which regulate the response of natural killer (NK) cells. The HLA complex is found on the short arm of chromosome 6 and is the most polymorphic region in the human genome. Africans are genetically more diverse than other populations; however, information on HLA diversity among southern Africans, including South African populations, is limited. Paucity of African HLA data limits our understanding of disease associations, the ability to identify donor-recipient matches for transplantation and the development of disease-specific vaccines. This review discusses the importance of HLA in the clinical setting in South Africans and highlights how tools such as HLA imputation might augment standard HLA typing methods to increase our understanding of HLA diversity in our populations, which will better inform disease association studies, donor recruitment strategies into bone marrow registries and our understanding of human genetic diversity in South Africa.en_ZA
dc.description.departmentImmunologyen_ZA
dc.description.librarianpm2020en_ZA
dc.description.urihttp://www.samj.org.zaen_ZA
dc.identifier.citationMellet, J., Tshabalala, M., Agbedare, O., Meyer, P.W.A., Gray, C.M. & Pepper, M.S. 2019,' Human leukocyte antigen (HLA) diversity and clinical applications in South Africa', South African Medical Journal, vol. 109, no.8, pp. S30-S34.en_ZA
dc.identifier.issn2078-5135 (online)
dc.identifier.issn0256-9574 (print)
dc.identifier.other10.7196/SAMJ.2019.v109i8b.13825
dc.identifier.urihttp://hdl.handle.net/2263/74750
dc.language.isoenen_ZA
dc.publisherHealth and Medical Publishing Groupen_ZA
dc.rights© 2019, South African Medical Association. This article is licensed under a Creative Commons Attribution-NonCommercial Works License (CC BY-NC 3.0).en_ZA
dc.subjectHuman leukocyte antigen (HLA)en_ZA
dc.subjectSouth Africa (SA)en_ZA
dc.subjectT cell immunityen_ZA
dc.subjectKillercell immunoglobulin-like receptor (KIR)en_ZA
dc.titleHuman leukocyte antigen (HLA) diversity and clinical applications in South Africaen_ZA
dc.typeArticleen_ZA

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