Widespread metastasis of a spermatocytic seminoma with concomitant hepatic peliosis in a Southern African hedgehog (Atelerixfrontalis)

dc.contributor.authorO'Dell, Nicolize
dc.contributor.authorO'Dell, Jacques Henry
dc.contributor.authorVan der Weyden, L.
dc.contributor.emailnicolize.odell@up.ac.zaen_US
dc.date.accessioned2023-08-28T10:31:48Z
dc.date.available2023-08-28T10:31:48Z
dc.date.issued2022
dc.description.abstractA six-year-old intact male Southern African hedgehog (Atelerix frontalis) presented with a history of chronic mild to moderate weight loss, and sub-acute hind limb ataxia that progressed to complete paralysis, at which point the hedgehog was euthanised. At autopsy, a large multinodular pale mass had completely replaced the left testicle and transcoelomically metastasised to the diaphragm and the peri-renal area, from where it then invaded the vertebral column and spinal cord. Multifocal, irregular to round, well-demarcated, blood-filled, proliferative lesions were also present in the hepatic parenchyma. Histological analysis of both the testis and metastatic lesions revealed diffuse sheets of neoplastic cells with moderate pale cytoplasm, large irregular to round nuclei and mostly one prominent magenta nucleolus, consistent with metastatic seminoma. The neoplastic cells were negative for periodic acid–Schiff (PAS) stain and positive for CD117 by immunohistochemistry (IHC). Taken together with the morphology of the neoplastic cells and the advanced age of the animal, this is suggestive of a spermatocytic seminoma. Histological analysis of the liver revealed multifocal lesions consisting of large anastomosing blood-filled spaces bordered by compressed hepatocytes, consistent with hepatic peliosis. This is the first report of a neoplasm in the Southern African hedgehog (Atelerix frontalis), the first report of a metastatic seminoma in a hedgehog, together with diagnosis of spermatocytic subtype, and the first report of a hedgehog with concomitant hepatic peliosis.en_US
dc.description.departmentCentre for Veterinary Wildlife Studiesen_US
dc.description.departmentParaclinical Sciencesen_US
dc.description.departmentProduction Animal Studiesen_US
dc.description.librarianam2023en_US
dc.description.sponsorshipThe Wellcome Trust.en_US
dc.description.urihttp://www.jsava.co.zaen_US
dc.identifier.citationO'Dell, N., O'Dell, J.H., Van der Weyden, L. 2022, 'Widespread metastasis of a spermatocytic seminoma with concomitant hepatic peliosis in a Southern African hedgehog (Atelerix frontalis)', Journal of the South African Veterinary Association, vol. 93, no. 1, pp. 1-4. https://DOI.org/10.36303/JSAVA.2022.93.1.492.en_US
dc.identifier.issn1019-9128 (print)
dc.identifier.issn2224-9435 (online)
dc.identifier.other10.36303/JSAVA.2022.93.1.492
dc.identifier.urihttp://hdl.handle.net/2263/92070
dc.language.isoenen_US
dc.publisherMedpharm Publicationsen_US
dc.rights© 2022 The Author(s). Open Access article distributed under the terms of the Creative Commons License [CC BY-NC 3.0].en_US
dc.subjectSeminomaen_US
dc.subjectAtelerix frontalisen_US
dc.subjectSpermatocyticen_US
dc.subjectHepatic peliosisen_US
dc.subjectSouthern African hedgehog (Atelerix frontalis)en_US
dc.subjectSDG-03: Good health and well-beingen_US
dc.titleWidespread metastasis of a spermatocytic seminoma with concomitant hepatic peliosis in a Southern African hedgehog (Atelerixfrontalis)en_US
dc.typeArticleen_US

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