Mosquito larvicidal activity of Cassia tora seed extract and its key anthraquinones aurantio-obtusin and obtusin

dc.contributor.authorMbatchou, Valentine C.
dc.contributor.authorTchouassi, David Poumo
dc.contributor.authorDickson, Rita A.
dc.contributor.authorAnnan, Kofi Ahomkah
dc.contributor.authorMensah, Abraham Y.
dc.contributor.authorAmponsah, Isaac K.
dc.contributor.authorJacob, Julia W.
dc.contributor.authorCheseto, Xavier
dc.contributor.authorHabtemariam, Solomon
dc.contributor.authorTorto, Baldwyn
dc.date.accessioned2018-03-12T10:15:35Z
dc.date.available2018-03-12T10:15:35Z
dc.date.issued2017-11-10
dc.description.abstractBACKGROUND : The edible and medicinal leguminous plant Cassia tora L. (Fabaceae) is known to possess insecticidal properties against a wide range of plant-feeding insects. However, the bioactivity of extracts of this plant and their constituents against vectors of medical importance has been largely unexplored. We investigated the mosquito larvicidal activity of the seed extract and its major anthraquinones against larvae of the African malaria vector Anopheles gambiae (s.s.). METHODS : Third-fourth instar larval mortality was observed after 24, 48, 72 and 96 h of exposure to varying doses of the extracts, and two anthraquinones isolates identified using liquid chromatography- quadrupole time of flight mass spectrometry (LC-QtoF-MS). The mosquito larval mortality was evaluated relative to the natural insecticide azadirachtin. RESULTS : Fractionation of the crude extract decreased mosquito larvicidal activity, however, larvicidal activity increased with increasing dose of the treatment and exposure time. The known anthraquinones aurantio-obtusin and obtusin were identified as key larvicidal compounds. Aurantio-obtusin and obtusin, exhibited similar toxicity to larvae of A. gambiae (s.s.) with LD50 values of 10 and 10.2 ppm, respectively. However, the two anthraquinones were four- and ~ six-fold less potent than that of the crude seed extract and azadirachtin, which had comparable LD50 values of 2.5 and 1.7 ppm, respectively. CONCLUSION : Both aurantio-obtusin and obtusin showed mosquito larvicidal activity which were comparable to their respective fractions although they were less potent relative to the crude extract and azadirachtin. Further studies need to be conducted on C. tora for its exploitation as a potential eco-friendly tool in mosquito larval source reduction.en_ZA
dc.description.departmentZoology and Entomologyen_ZA
dc.description.librarianam2018en_ZA
dc.description.sponsorshipSwedish International Development Cooperation Agency (SIDA) for a studentship to VCM, UK's Department for International Development (DFID), the Swiss Agency for Development and Cooperation (SDC), and the Kenyan Government.en_ZA
dc.description.urihttp://www.parasitesandvectors.comen_ZA
dc.identifier.citationMbatchou, V.C., Tchouassi, D.P., Dickson, R.A. et al. 2017, 'Mosquito larvicidal activity of Cassia tora seed extract and its key anthraquinones aurantio-obtusin and obtusin', Parasites & Vectors, vol. 10, art. no. 562, pp. 1-8.en_ZA
dc.identifier.issn1756-3305 (online)
dc.identifier.other10.1186/s13071-017-2512-y
dc.identifier.urihttp://hdl.handle.net/2263/64210
dc.language.isoenen_ZA
dc.publisherBioMed Centralen_ZA
dc.rights© The Author(s). 2017. Open Access. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License.en_ZA
dc.subjectCassia toraen_ZA
dc.subjectAurantio-obtusinen_ZA
dc.subjectObtusinen_ZA
dc.subjectAnthraquinoneen_ZA
dc.subjectMosquito larvicidal activityen_ZA
dc.subjectAnopheles gambiae S.Sen_ZA
dc.subjectTurraea wakefieldiien_ZA
dc.subjectInhibitory activityen_ZA
dc.subjectDerivativesen_ZA
dc.subjectLimonoidsen_ZA
dc.subjectGlycationen_ZA
dc.subjectProductsen_ZA
dc.titleMosquito larvicidal activity of Cassia tora seed extract and its key anthraquinones aurantio-obtusin and obtusinen_ZA
dc.typeArticleen_ZA

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