Association between exposure to drinking water disinfection byproducts and adverse pregnancy outcomes in South Africa

dc.contributor.authorMashau, Funanani
dc.contributor.authorNcube, Esper Jacobeth
dc.contributor.authorVoyi, K.V.V. (Kuku)
dc.date.accessioned2022-05-17T03:37:00Z
dc.date.available2022-05-17T03:37:00Z
dc.date.issued2021
dc.description.abstractCurrently, there is contradictory evidence for the risk of adverse pregnancy outcomes associated with maternal exposure to disinfection byproducts (DBPs). We examine the association between maternal exposure to trihalomethanes (THMs) in drinking water and adverse pregnancy outcomes, including premature birth, low birth weight (LBW) and small for gestational age (SGA). In total, 1,167 women older than 18 years were enrolled at public antenatal venues in two geographical districts. For each district, we measured the levels of residential drinking water DBPs (measured in THMs) through regulatory data and routine water sampling. We estimated the individual uptake of water of each woman by combining individual water use and uptake factors. Increased daily internal dose of total THMs during the third trimester of pregnancy significantly increased the risk of delivering premature infants (AOR 3.13, 95% CI 1.36–7.17). The risk of premature birth was also positiviely associated with exposure to total THMs during the whole pregnancy (AOR 2.89, 95% CI 1.25–6.68). The risk of delivering an SGA and LBW infant was not associated with maternal exposure to THMs. Our findings suggest that exposure to THMs is associated with certain negative pregnancy outcomes. The levels of THMs in water should be routinely monitored.en_US
dc.description.departmentSchool of Health Systems and Public Health (SHSPH)en_US
dc.description.librarianam2022en_US
dc.description.sponsorshipThis work was supported by the South African National Research Foundation (NRF) (Grant number SFH150625121049).en_US
dc.description.urihttp://www.iwaponline.com/jwh/default.htmen_US
dc.identifier.citationMashau, F. Ncube, E.J., Voyi, K. 2021, 'Association between exposure to drinking water disinfection byproducts and adverse pregnancy outcomes in South Africa', Journal of Water and Health, vol. 19, no. 1, pp. 174-189.en_US
dc.identifier.issn1477-8920
dc.identifier.other10.2166/wh.2020.214
dc.identifier.urihttps://repository.up.ac.za/handle/2263/85220
dc.language.isoenen_US
dc.publisherIWA Publishingen_US
dc.rights© 2021 The Authors. This is an Open Access article distributed under the terms of the Creative Commons Attribution Licence (CC BY-NC-ND 4.0).en_US
dc.subjectAdverse pregnancy outcomesen_US
dc.subjectDisinfection byproductsen_US
dc.subjectDrinking wateren_US
dc.subjectTrihalomethanes (THMs)en_US
dc.subjectSub-Saharan Africa (SSA)en_US
dc.subjectDisinfection byproducts (DBPs)en_US
dc.subjectSmall for gestational age (SGA)en_US
dc.subjectPremature birthen_US
dc.subjectLow birth weight (LBW)en_US
dc.titleAssociation between exposure to drinking water disinfection byproducts and adverse pregnancy outcomes in South Africaen_US
dc.typeArticleen_US

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