Association between gestational diabetes and biomarkers : a role in diagnosis

dc.contributor.authorAdam, Sumaiya
dc.contributor.authorPheiffer, Carmen
dc.contributor.authorDias, Stephanie Charmaine
dc.contributor.authorRheeder, Paul
dc.contributor.emailsumaiya.adam@up.ac.zaen_ZA
dc.date.accessioned2019-04-05T05:17:21Z
dc.date.available2019-04-05T05:17:21Z
dc.date.issued2018
dc.description.abstractBACKGROUND : We investigated the association between markers of insulin resistance, chronic inflammation, and adipokines and GDM. METHODS : In our case-cohort study in Johannesburg we included women with GDM and controls. We tested the ability of biomarkers to identify women at high risk of GDM. RESULTS : Of the 262 pregnant women, 83 (31.7%) had GDM. Women with GDM were heavier (p = 0.04) and had more clinical risk factors (p = 0.008). We found a significant difference in fasting insulin (p < 0.001), adiponectin (p = 0.046), HOMA (p < 0.001) and QUICKI (p < 0.001). HOMA (AUROC = 0.82) or QUICKI (AUROC = 0.82) improved the ability of risk factors to identify women at high risk of GDM. CONCLUSIONS : Insulin sensitivity markers are promising tools to identify women at high risk of GDM.en_ZA
dc.description.departmentInternal Medicineen_ZA
dc.description.departmentObstetrics and Gynaecologyen_ZA
dc.description.librarianhj2019en_ZA
dc.description.sponsorshipThe Society for Endocrinology, Metabolism and Diabetes of South Africa (SEMDSA), South African Sugar Association (SASA), and Roche Pharmaceuticals.en_ZA
dc.description.urihttp://www.tandfonline.com/loi/ibmk20en_ZA
dc.identifier.citationAdam, S., Pheiffer, C., Dias, S. et al. 2018, 'Association between gestational diabetes and biomarkers : a role in diagnosis', Biomarkers, vol. 23, no. 4, pp. 386-391.en_ZA
dc.identifier.issn1354-750X (print)
dc.identifier.issn1366-5804 (online)
dc.identifier.other10.1080/1354750X.2018.1432690
dc.identifier.urihttp://hdl.handle.net/2263/68921
dc.language.isoenen_ZA
dc.publisherTaylor and Francisen_ZA
dc.rights© 2018 Informa UK Limited, trading as Taylor & Francis Group. This is an electronic version of an article published in Biomarkers, vol. 23, no. 4, pp. 386-391, 2018. doi : 10.1080/1354750X.2018.1432690. Biomarkers is available online at : http://www.tandfonline.com/loi/ibmk20.en_ZA
dc.subjectProteinen_ZA
dc.subjectPregnancyen_ZA
dc.subjectAdiponectinen_ZA
dc.subjectWomenen_ZA
dc.subjectType 2 diabetes mellitus (T2DM)en_ZA
dc.subjectInsulin sensitivityen_ZA
dc.subjectBiomarkersen_ZA
dc.subjectGestational diabetes (GDM)en_ZA
dc.titleAssociation between gestational diabetes and biomarkers : a role in diagnosisen_ZA
dc.typePostprint Articleen_ZA

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