Labdane diterpenoids from Leonotis ocymifolia with selective cytotoxic activity against HCC70 breast cancer cell line

dc.contributor.authorNcongwane, Jane Busisiwe
dc.contributor.authorTembu, Vuyelwa Jacqueline
dc.contributor.authorNkambule, Comfort Mduduzi
dc.contributor.authorKemboi, Douglas
dc.contributor.authorFouche, Gerda
dc.contributor.authorVukea, Nyeleti
dc.contributor.authorDe la Mare, Jo-Anne
dc.contributor.emailgerda.fouche@up.ac.za
dc.date.accessioned2025-11-26T12:07:07Z
dc.date.available2025-11-26T12:07:07Z
dc.date.issued2025-05-01
dc.descriptionDATA AVAILABILITY STATEMENT : Data are contained within the article and Supplementary Materials. SUPPLEMENTARY MATERIAL : TABLE S1: 1H (δH; J, Hz) NMR (400 MHZ) data for compounds 1–6; TABLE S2: 13C (δc) (100.6 MHz) NMR data for compounds 1-6 and spectral data for compounds 1–6 (APPENDIX 1–27).
dc.description.abstractPlease read abstract in the article.
dc.description.departmentChemistry
dc.description.librarianhj2025
dc.description.sdgSDG-03: Good health and well-being
dc.description.sponsorshipThis research was funded by NRF, South Africa. National Research Foundation, Rhodes University; Tshwane University of Technology, Pretoria, South Africa.
dc.description.urihttps://www.mdpi.com/journal/diseases
dc.identifier.citationNcongwane, J.B.; Tembu, V.J.; Nkambule, C.M.; Kemboi, D.; Fouche, G.; Vukea, N.; de la Mare, J.-A. Labdane Diterpenoids from Leonotis ocymifolia with Selective Cytotoxic Activity Against HCC70 Breast Cancer Cell Line. Diseases 2025, 13, 140. https://doi.org/10.3390/ diseases13050140.
dc.identifier.issn2079-9721 (online)
dc.identifier.other10.3390/ diseases13050140
dc.identifier.urihttp://hdl.handle.net/2263/105521
dc.language.isoen
dc.publisherMDPI
dc.rights© 2025 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
dc.subjectTriple-negative breast cancer (TNBC)
dc.subjectLeonotis ocymifolia
dc.subjectBreast cancer
dc.subjectLabdane diterpenoids
dc.subjectBis-spirolabdane
dc.subjectMCF-7
dc.subjectHCC70
dc.subjectCytotoxic activity
dc.titleLabdane diterpenoids from Leonotis ocymifolia with selective cytotoxic activity against HCC70 breast cancer cell line
dc.typeArticle

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