Similarities between tumour immune response and chronic wound microenvironment : influence of mesenchymal stromal/stem cells

dc.contributor.authorPeta, Kimberly Thando
dc.contributor.authorAmbele, Melvin Anyasi
dc.contributor.authorPepper, Michael Sean
dc.contributor.emailmichael.pepper@up.ac.zaen_US
dc.date.accessioned2022-09-02T12:15:44Z
dc.date.available2022-09-02T12:15:44Z
dc.date.issued2021-03-30
dc.description.abstractTumours are characterized by a state of chronic inflammation and are regarded as wounds that never heal. Mesenchymal stromal/stem cells (MSCs) are being considered as a possible treatment option. While MSCs can regulate the immune system, migrate to sites of inflammation, and are naturally immune-privileged, there have been contradictory reports on the role of these cells in the tumour microenvironment (TME). Some studies have suggested that MSCs promote tumourigenesis while others have suggested the contrary. To better evaluate the role of MSCs in the TME, it may be helpful to understand the role of MSCs in chronic wounds. Here, we discuss the role of MSCs in chronic wounds and extrapolate this to the TME. Chronic wounds are stuck in the inflammatory phase of wound healing, while in the case of the TME, both the inflammatory and proliferative phases are exploited. MSCs in chronic wounds promote a switch in macrophage phenotype from proinflammatory (M1) to anti-inflammatory (M2), thereby suppressing T, B, and natural killer cells, consequently promoting wound healing. In the case of the TME, MSCs are reported to promote tumorigenesis by suppressing T, B, and natural killer cells in addition to dendritic cells, cytotoxic T cells, and Th1-associated cytokines, thereby promoting tumour growth. Some studies have however suggested that MSCs inhibit tumourigenesis, depending on the source of the MSCs and the specific mediators involved. Therefore, the role of MSCs in the TME appears to be complex and may result in variable outcomes. Compelling evidence to suggest that MSCs are an effective treatment option against tumour progression is lacking.en_US
dc.description.departmentImmunologyen_US
dc.description.departmentOral Pathology and Oral Biologyen_US
dc.description.librarianam2022en_US
dc.description.sponsorshipThe South African Medical Research Council University Flagship Project, the SAMRC Extramural Unit for Stem Cell Research and Therapy, and the Institute for Cellular and Molecular Medicine of the University of Pretoria; the South African Medical Research Council Self-Initiated Research Grant and M.A.A by the National Research Foundation Competitive Support for Unrated Researchers.en_US
dc.description.urihttp://www.hindawi.com/journals/jiren_US
dc.identifier.citationPeta, K.T., Ambele, M.A., Pepper, M.S. 2021, 'Similarities between tumour immune response and chronic wound microenvironment : influence of mesenchymal stromal/stem cells', Journal of Immunology Research, vol. 2021, art. 664314, pp. 1-11, doi : 10.1155/2021/6649314.en_US
dc.identifier.issn2314-8861 (print)
dc.identifier.issn2314-7156 (online)
dc.identifier.other10.1155/2021/6649314
dc.identifier.urihttps://repository.up.ac.za/handle/2263/87049
dc.language.isoenen_US
dc.publisherHindawien_US
dc.rights© 2021 Kimberly Thando Peta et al. This is an open access article distributed under the Creative Commons Attribution License.en_US
dc.subjectTumoursen_US
dc.subjectWoundsen_US
dc.subjectTreatmenten_US
dc.subjectTumour microenvironmenten_US
dc.subjectMesenchymal stromal/stem cells (MSCs)en_US
dc.subjectTumour microenvironment (TME)en_US
dc.titleSimilarities between tumour immune response and chronic wound microenvironment : influence of mesenchymal stromal/stem cellsen_US
dc.typeArticleen_US

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