Inhaled microparticles containing clofazimine are efficacious in treatment of experimental tuberculosis in mice
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Date
Authors
Verma, Rahul Kumar
Germishuizen, Willem Andreas
Motheo, M.P. (Mamofalali Portia)
Agrawal, Atul Kumar
Singh, Amit Kumar
Mohan, Mradul
Gupta, Pushpa
Gupta, Umesh Datta
Cholo, Moloko C.
Anderson, Ronald
Journal Title
Journal ISSN
Volume Title
Publisher
American Society for Microbiology
Abstract
Inhalable clofazimine-containing dry powder microparticles (CFM-DPI) and native clofazimine (CFM) were evaluated for activity against Mycobacterium tuberculosis in human monocyte-derived macrophage cultures and in mice infected with a low-dose aerosol. Both formulations resulted in 99% killing at 2.5 g/ml in vitro. In mice, 480 g and 720 g CFM-DPI inhaled twice per week over 4 weeks reduced numbers of CFU in the lung by as much as log10 2.6; 500 g oral CFM achieved a log10 0.7 reduction.
Description
Keywords
Microparticles, Clofazimine, Treatment, Mice
Sustainable Development Goals
Citation
Verma, RK, Germishuizen, WA, Motheo, MP, Agrawal, AK, Singh, AK, Mohan, M, Gupta, P, Gupta, UD, Cholo, M, Anderson, R, Fourie, PB & Misra, A 2013, 'Inhaled microparticles containing clofazimine are efficacious in treatment of experimental tuberculosis in mice', Antimicrobial Agents and Chemotherapy , vol. 57, no. 2, pp. 1050-1052.