The simultaneous occurrence of both hypercoagulability and hypofibrinolysis in blood and serum during systemic inflammation, and the roles of iron and fibrin(ogen)

dc.contributor.authorKell, Douglas B.
dc.contributor.authorPretorius, Etheresia
dc.contributor.emailresia.pretorius@up.ac.zaen_ZA
dc.date.accessioned2015-02-18T10:32:58Z
dc.date.available2015-02-18T10:32:58Z
dc.date.issued2015-01
dc.description.abstractAlthough the two phenomena are usually studied separately, we summarise a considerable body of literature to the effect that a great many diseases involve (or are accompanied by) both an increased tendency for blood to clot (hypercoagulability) and the resistance of the clots so formed (hypofibrinolysis) to the typical, ‘healthy’ or physiological lysis. We concentrate here on the terminal stages of fibrin formation from fibrinogen, as catalysed by thrombin. Hypercoagulability goes hand in hand with inflammation, and is strongly influenced by the fibrinogen concentration (and vice versa); this can be mediated via interleukin-6. Poorly liganded iron is a significant feature of inflammatory diseases, and hypofibrinolysis may change as a result of changes in the structure and morphology of the clot, which may be mimicked in vitro, and may be caused in vivo, by the presence of unliganded iron interacting with fibrin(ogen) during clot formation. Many of these phenomena are probably caused by electrostatic changes in the iron–fibrinogen system, though hydroxyl radical (OH ) formation can also contribute under both acute and (more especially) chronic conditions. Many substances are known to affect the nature of fibrin polymerised from fibrinogen, such that this might be seen as a kind of bellwether for human or plasma health. Overall, our analysis demonstrates the commonalities underpinning a variety of pathologies as seen in both hypercoagulability and hypofibrinolysis, and offers opportunities for both diagnostics and therapies.en_ZA
dc.description.embargo2016-01-30en_ZA
dc.description.librarianhb2015en_ZA
dc.description.sponsorshipBiotechnology and Biological Sciences Research Council (BB/L025752/1)en_ZA
dc.description.urihttp://www.rsc.org/ibiologyen_ZA
dc.identifier.citationKell, D & Pretorius, E 2015, 'The simultaneous occurrence of both hypercoagulability and hypofibrinolysis in blood and serum during systemic inflammation, and the roles of iron and fibrin(ogen)', Integrative Biology, vol. 7, pp. 24-52.en_ZA
dc.identifier.issn1757-9694 (print)
dc.identifier.issn1757-9708 (online)
dc.identifier.other10.1039/C4IB00173G
dc.identifier.urihttp://hdl.handle.net/2263/43714
dc.language.isoenen_ZA
dc.publisherRoyal Society of Chemistryen_ZA
dc.rights© The Royal Society of Chemistry 2015en_ZA
dc.subjectSimultaneous occurrenceen_ZA
dc.subjectHypercoagulabilityen_ZA
dc.subjectHypofibrinolysisen_ZA
dc.subjectSerumen_ZA
dc.subjectSystemic inflammationen_ZA
dc.titleThe simultaneous occurrence of both hypercoagulability and hypofibrinolysis in blood and serum during systemic inflammation, and the roles of iron and fibrin(ogen)en_ZA
dc.typePostprint Articleen_ZA

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