Phenotypic characteristics of Hydrocephalus in stillborn Friesian foals

dc.contributor.authorSipma, K.D.
dc.contributor.authorCornillie, P.
dc.contributor.authorSaulez, Montague Newton
dc.contributor.authorStout, T.A.E. (Tom)
dc.contributor.authorVoorhout, G.
dc.contributor.authorBack, W.
dc.date.accessioned2014-06-18T10:26:06Z
dc.date.available2014-06-18T10:26:06Z
dc.date.issued2013-05-15
dc.description.abstractHydrocephalus is uncommon in horses. However, in recent years, it has become clear that the prevalence of hydrocephalus is greater in Friesian horses than in other breeds probably due to their limited gene pool. Before identification of candidate genes that predispose to the development of hydrocephalus in Friesian horses can be pursued, an in-depth, phenotypic, pathological description of the condition in Friesians would be of great benefit. Our study aimed to characterize the morphology of hydrocephalus in Friesian horses, to support further investigation of the genetic background of this condition. Four stillborn Friesian foals with hydrocephalus were examined macroscopically and microscopically and compared with 2 normal stillborn Friesian foals without hydrocephalus. In all clinical cases, tetraventricular and venous dilatations were observed, together with malformation of the petrosal bone and, as a result, narrowing of the jugular foramen. These observations suggest a communicative hydrocephalus with a diminished absorption of cerebrospinal fluid into the systemic circulation at the venous sinuses due to a distorted, nonfunctional jugular foramen. This type of hydrocephalus is also recognized in humans and dogs and has been linked genetically to chondrodysplasia; this has already been recognized in dwarfism, which is another monogenetic defect in Friesian horses.en_US
dc.description.librarianam2014en_US
dc.description.urihttp://vet.sagepub.com/en_US
dc.identifier.citationSipma, KD, Cornillie, P, Saulez, MN, Stout, TAE, Voorhout, G & Back, W 2013, 'Phenotypic characteristics of Hydrocephalus in stillborn Friesian foals', Verterinary Pathology, vol. 50, no. 6, pp. 1037-1042.en_US
dc.identifier.issn0300-9858 (print)
dc.identifier.issn1544-2217 (online)
dc.identifier.other10.1177/0300985813488955
dc.identifier.urihttp://hdl.handle.net/2263/40284
dc.language.isoenen_US
dc.publisherSageen_US
dc.rights© The Author(s) 2013en_US
dc.subjectHorsesen_US
dc.subjectHydrocephalusen_US
dc.subjectJugular foramenen_US
dc.subjectPhenotypeen_US
dc.subjectStillbirthen_US
dc.subjectFriesian foals
dc.titlePhenotypic characteristics of Hydrocephalus in stillborn Friesian foalsen_US
dc.typeArticleen_US

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