The efficacy of a generic doxycycline tablet in the treatment of canine monocytic ehrlichiosis

dc.contributor.authorFourie, Josephus J.
dc.contributor.authorHorak, Ivan Gerard
dc.contributor.authorCrafford, Dionne
dc.contributor.authorErasmus, Heidi L.
dc.contributor.authorBotha, Ockert J.
dc.date.accessioned2015-08-03T09:00:27Z
dc.date.available2015-08-03T09:00:27Z
dc.date.issued2015-03-25
dc.description.abstractThe objective of the present study was to evaluate the therapeutic efficacy of a generic doxycycline tablet (DoxyVet®) against Ehrlichia canis infection in dogs. Canine monocytic ehrlichiosis is caused by the bacterium E. canis and transmitted by the brown kennel tick (Rhipicephalus sanguineus). Six disease-free and tick-free dogs were infested with E. canisinfected ticks. Once diagnosed (with polymerase chain reaction [PCR] analysis and platelet counts) as positive for infection, doxycycline tablets were administered orally once a day for 20 consecutive days, at a target dose level of 10 mg/kg. The actual dose administered was calculated as ranging between 10 mg/kg and 11.7 mg/kg. The PCR analysis, 28 days after the first administration of the tablets, failed to detect E. canis in any of the dogs. On Day 56 of the study, four of the dogs were diagnosed with E. canis for the second time and a fifth dog was diagnosed on Day 70. The platelet counts of the sixth dog remained within normal levels and it was discharged from the study on Day 84. Doxycycline tablets were then administered to the remaining five infected dogs for 28 consecutive days. Four of these dogs had no positive PCR results during the following 3 months. The fifth dog was diagnosed with E. canis for the third time 58 days after the last tablets of the second treatment had been administered, after which it was rescue treated (doxycycline for a further 28 days). The results indicate that doxycycline administered in tablet form (DoxyVet®) at 10 mg/kg – 11.7 mg/kg body mass once daily for 28 consecutive days clears most dogs of infection. The importance of a concomitant tick-control programme is therefore stressed.en_ZA
dc.description.librarianam2015en_ZA
dc.description.urihttp://www.jsava.co.zaen_ZA
dc.identifier.citationFourie, J.J., Horak, I., Crafford, D., Erasmus, H.L. & Botha, O.J., 2015, ‘The efficacy of a generic doxycycline tablet in the treatment of canine monocytic ehrlichiosis’, Journal of the South African Veterinary Association 86(1), Art. #1193, 10 pages. http://dx.DOI.org/ 10.4102/jsava.v86i1.1193.en_ZA
dc.identifier.issn1019-9128 (print)
dc.identifier.issn2224-9435 (online)
dc.identifier.other10.4102/jsava.v86i1.1193
dc.identifier.other7102989086
dc.identifier.urihttp://hdl.handle.net/2263/49226
dc.language.isoenen_ZA
dc.publisherAOSIS OpenJournalsen_ZA
dc.relation.requiresAdobe Acrobat Readeren
dc.rights© 2015. The Authors. Licensee: AOSIS OpenJournals. This work is licensed under the Creative Commons Attribution License.en_ZA
dc.subjectDoxycycline tableten_ZA
dc.subjectEhrlichia canisen_ZA
dc.subjectInfectionen_ZA
dc.subjectDogsen_ZA
dc.titleThe efficacy of a generic doxycycline tablet in the treatment of canine monocytic ehrlichiosisen_ZA
dc.typeArticleen_ZA

Files

Original bundle

Now showing 1 - 1 of 1
Loading...
Thumbnail Image
Name:
Fourie_Efficacy_2015.pdf
Size:
377.04 KB
Format:
Adobe Portable Document Format
Description:
Article

License bundle

Now showing 1 - 1 of 1
Loading...
Thumbnail Image
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed upon to submission
Description: