Differential mortality risks associated with PM2.5 components : a multi-country, multi-city study

dc.contributor.authorMasselot, Pierre
dc.contributor.authorSera, Francesco
dc.contributor.authorSchneider, Rochelle
dc.contributor.authorKan, Haidong
dc.contributor.authorLavigne, Eric
dc.contributor.authorStafoggia, Massimo
dc.contributor.authorTobias, Aurelio
dc.contributor.authorChen, Hong
dc.contributor.authorBurnett, Richard T.
dc.contributor.authorSchwartz, Joel
dc.contributor.authorZanobetti, Antonella
dc.contributor.authorBell, Michelle L.
dc.contributor.authorChen, Bing-Yu
dc.contributor.authorGuo, Yue-Liang Leon
dc.contributor.authorRagettli, Martina S.
dc.contributor.authorVicedo-Cabrera, Ana Maria
dc.contributor.authorAstrom, Christofer
dc.contributor.authorForsberg, Bertil
dc.contributor.authorIniguez, Carmen
dc.contributor.authorGarland, Rebecca M.
dc.contributor.authorScovronick, Noah
dc.contributor.authorMadureira, Joana
dc.contributor.authorNunes, Baltazar
dc.contributor.authorDe la Cruz Valencia, Cesar
dc.contributor.authorHurtado Diaz, Magali
dc.contributor.authorHonda, Yasushi
dc.contributor.authorHashizume, Masahiro
dc.contributor.authorNg, Chris Fook Cheng
dc.contributor.authorSamoli, Evangelia
dc.contributor.authorKatsouyanni, Klea
dc.contributor.authorSchneider, Alexandra
dc.contributor.authorBreitner, Susanne
dc.contributor.authorRyti, Niilo R.I.
dc.contributor.authorJaakkola, Jouni J.K.
dc.contributor.authorMaasikmets, Marek
dc.contributor.authorOrru, Hans
dc.contributor.authorGuo, Yuming
dc.contributor.authorValdes Ortega, Nicolas
dc.contributor.authorMatus Correa, Patricia
dc.contributor.authorTong, Shilu
dc.contributor.authorGasparrini, Antonio
dc.date.accessioned2022-03-15T08:59:18Z
dc.date.issued2022-03
dc.description.abstractBACKGROUND : The association between fine particulate matter (PM2.5) and mortality widely differs between as well as within countries. Differences in PM2.5 composition can play a role in modifying the effect estimates, but there is little evidence about which components have higher impacts on mortality. METHODS : We applied a 2-stage analysis on data collected from 210 locations in 16 countries. In the first stage, we estimated location-specific relative risks (RR) for mortality associated with daily total PM2.5 through time series regression analysis. We then pooled these estimates in a meta-regression model that included city-specific logratio-transformed proportions of seven PM2.5 components as well as meta-predictors derived from city-specific socio-economic and environmental indicators. RESULTS : We found associations between RR and several PM2.5 components. Increasing the ammonium (NH4+) proportion from 1% to 22%, while keeping a relative average proportion of other components, increased the RR from 1.0063 (95% confidence interval [95% CI] = 1.0030, 1.0097) to 1.0102 (95% CI = 1.0070, 1.0135). Conversely, an increase in nitrate (NO3-) from 1% to 71% resulted in a reduced RR, from 1.0100 (95% CI = 1.0067, 1.0133) to 1.0037 (95% CI = 0.9998, 1.0077). Differences in composition explained a substantial part of the heterogeneity in PM2.5 risk. CONCLUSIONS : These findings contribute to the identification of more hazardous emission sources. Further work is needed to understand the health impacts of PM2.5 components and sources given the overlapping sources and correlations among many components.en_ZA
dc.description.departmentGeography, Geoinformatics and Meteorologyen_ZA
dc.description.embargo2023-03-01
dc.description.librarianhj2022en_ZA
dc.description.urihttp://journals.lww.com/epidem/pages/default.aspxen_ZA
dc.identifier.citationMasselot P, Sera F, Schneider R, Kan H, Lavigne É, Stafoggia M, Tobias A, Chen H, Burnett RT, Schwartz J, Zanobetti A, Bell ML, Chen BY, Guo YL, Ragettli MS, Vicedo-Cabrera AM, Åström C, Forsberg B, Íñiguez C, Garland RM, Scovronick N, Madureira J, Nunes B, De la Cruz Valencia C, Hurtado Diaz M, Honda Y, Hashizume M, Ng CFC, Samoli E, Katsouyanni K, Schneider A, Breitner S, Ryti NRI, Jaakkola JJK, Maasikmets M, Orru H, Guo Y, Valdés Ortega N, Matus Correa P, Tong S, Gasparrini A. Differential Mortality Risks Associated With PM2.5 Components: A Multi-Country, Multi-City Study. Epidemiology. 2022 Mar 1;33(2):167-175. doi: 10.1097/EDE.0000000000001455.en_ZA
dc.identifier.issn1044-3983 (print)
dc.identifier.issn1531-5487 (online)
dc.identifier.other10.1097/EDE.0000000000001455
dc.identifier.urihttp://hdl.handle.net/2263/84490
dc.language.isoenen_ZA
dc.publisherLippincott Williams and Wilkinsen_ZA
dc.rights© 2021 Wolters Kluwer Health / Lippincott Williams & Wilkins. This is a non-final version of an article published in final form in Epidemiology. 2022 Mar 1;33(2):167-175. doi: 10.1097/EDE.0000000000001455.en_ZA
dc.subjectParticulate matter (PM2.5)en_ZA
dc.subjectMortalityen_ZA
dc.titleDifferential mortality risks associated with PM2.5 components : a multi-country, multi-city studyen_ZA
dc.typePostprint Articleen_ZA

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