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dc.contributor.author | Martin, C.![]() |
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dc.contributor.author | Clift, Sarah Jane![]() |
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dc.contributor.author | Leisewitz, Andrew L.![]() |
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dc.date.accessioned | 2024-08-15T10:50:52Z | |
dc.date.available | 2024-08-15T10:50:52Z | |
dc.date.issued | 2023-02 | |
dc.description.abstract | A proportion of Babesia rossi infections in dogs are classified as complicated and one of the most lethal complications is acute lung injury (ALI) and acute respiratory distress syndrome (ARDS). Most dogs that die succumb within 24 hours of presentation. The pulmonary pathology caused by B. rossi in dogs has not been described. The aim of this study was to provide a thorough macroscopic, histological and immunohistochemical description of the lung changes seen in dogs naturally infected with B. rossi that succumbed to the infection. Death was invariably accompanied by alveolar oedema. Histopathology showed acute interstitial pneumonia characterised by alveolar oedema and haemorrhages, with increased numbers of mononuclear leucocytes in alveolar walls and lumens. Intra-alveolar polymerised fibrin aggregates were observed in just over half the infected cases. Immunohistochemistry showed increased numbers of MAC387- and CD204-reactive monocyte-macrophages in alveolar walls and lumens, and increased CD3-reactive T-lymphocytes in alveolar walls, compared with controls. These histological features overlap to some extent (but far from perfectly) with the histological pattern of lung injury referred to as the exudative stage of diffuse alveolar damage (DAD) as is quite commonly reported in ALI/ARDS. | en_US |
dc.description.department | Companion Animal Clinical Studies | en_US |
dc.description.department | Paraclinical Sciences | en_US |
dc.description.librarian | am2024 | en_US |
dc.description.sdg | SDG-03:Good heatlh and well-being | en_US |
dc.description.sponsorship | The South African National Research Foundation. | en_US |
dc.description.uri | http://www.jsava.co.za | en_US |
dc.identifier.citation | Martin, C., Clift, S., Leisewitz, A. 2023, 'Lung pathology of natural Babesia rossi infection in dogs', Journal of the South African Veterinary Association, vol. 94, no. 1, pp. 59-69. https://DOI.org/10.36303/JSAVA.523. | en_US |
dc.identifier.issn | 2224-9435 (print) | |
dc.identifier.issn | 1019-9128 (online) | |
dc.identifier.other | 10.36303/JSAVA.523 | |
dc.identifier.uri | http://hdl.handle.net/2263/97662 | |
dc.language.iso | en | en_US |
dc.publisher | MedPharm Publications | en_US |
dc.rights | © 2023 The Author(s). Open Access article distributed under the terms of the Creative Commons License [CC BY-NC 3.0]. | en_US |
dc.subject | Babesiosis | en_US |
dc.subject | Immunohistochemistry | en_US |
dc.subject | Interstitial pneumonia | en_US |
dc.subject | Pulmonary | en_US |
dc.subject | Acute lung injury (ALI) | en_US |
dc.subject | Acute respiratory distress syndrome (ARDS) | en_US |
dc.subject | Dogs (Canis familiaris) | en_US |
dc.subject | SDG-03: Good health and well-being | en_US |
dc.title | Lung pathology of natural Babesia rossi infection in dogs | en_US |
dc.type | Article | en_US |