hERG, Plasmodium life cycle, and cross resistance profiling of new azabenzimidazole analogues of astemizole
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| dc.contributor.author | Mambwe, Dickson
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| dc.contributor.author | Coertzen, Dina
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| dc.contributor.author | Leshabane, Meta Kgaogelo
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| dc.contributor.author | Mulubwa, Mwila
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| dc.contributor.author | Njoroge, Mathew
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| dc.contributor.author | Gibhard, Liezl
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| dc.contributor.author | Girling, Gareth
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| dc.contributor.author | Wicht, Kathryn J.
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| dc.contributor.author | Lee, Marcus C.S.
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| dc.contributor.author | Wittlin, Sergio
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| dc.contributor.author | Moreira, Diogo Rodrigo Magalhaes
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| dc.contributor.author | Birkholtz, Lyn-Marie
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| dc.contributor.author | Chibale, Kelly
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| dc.date.accessioned | 2024-07-25T07:10:15Z | |
| dc.date.available | 2024-07-25T07:10:15Z | |
| dc.date.issued | 2024-03 | |
| dc.description | SUPPLEMENTARY INFORMATION : Experimental procedures and characterization data of synthetic intermediates (5a–5f, 6a–6f, 13, and 15) and target compounds (7–12 and 15); biochemical assay protocols, including solubility and cross-resistance studies; H NMR spectra of representative target compounds. | en_US |
| dc.description.abstract | Please read abstract in the article. | en_US |
| dc.description.department | Biochemistry | en_US |
| dc.description.department | Genetics | en_US |
| dc.description.department | Microbiology and Plant Pathology | en_US |
| dc.description.department | UP Centre for Sustainable Malaria Control (UP CSMC) | en_US |
| dc.description.librarian | hj2024 | en_US |
| dc.description.sdg | SDG-03:Good heatlh and well-being | en_US |
| dc.description.sponsorship | The University of Cape Town (UCT), South African Medical Research Council, the South African Research Chairs Initiative (SARChI) of the Department of Science and Innovation (DSI) administered through the South African National Research Foundation (NRF), the Brazilian National Council for Scientific and Technological Development, Proep-Fiocruz Program (Brazil), the Neville Isdell Chair in African-centric Drug Discovery and Development, and Neville Isdell for generously funding the Chair. | en_US |
| dc.description.uri | http://pubs.acs.org/journal/amclct | en_US |
| dc.identifier.citation | Mambwe, D., Coertzen, D., Leshabane, M. et al. 2024, 'hERG, Plasmodium life cycle, and cross resistance profiling of new azabenzimidazole analogues of astemizole', ACS Medicinal Chemistry Letters, vol. 15, no. 4, pp. 463-469, doi : 10.1021/acsmedchemlett.3c00496. | en_US |
| dc.identifier.issn | 1948-5875 (print) | |
| dc.identifier.other | 10.1021/acsmedchemlett.3c00496 | |
| dc.identifier.uri | http://hdl.handle.net/2263/97228 | |
| dc.language.iso | en | en_US |
| dc.publisher | American Chemical Society | en_US |
| dc.rights | © 2024 The Authors. Published by American Chemical Society. This article is licensed under CC-BY 4.0. | en_US |
| dc.subject | Astemizole | en_US |
| dc.subject | Plasmodium falciparum | en_US |
| dc.subject | Plasmodium berghei | en_US |
| dc.subject | Repositioning | en_US |
| dc.subject | Human ether-á-go-go-related gene (hERG) | en_US |
| dc.subject | Gametocytocidal | en_US |
| dc.subject | Liver-stage activity | en_US |
| dc.subject | Resistance phenotypes | en_US |
| dc.subject | SDG-03: Good health and well-being | en_US |
| dc.title | hERG, Plasmodium life cycle, and cross resistance profiling of new azabenzimidazole analogues of astemizole | en_US |
| dc.type | Article | en_US |
