Neuropathic pain in AIDS patients prior to antiretroviral therapy

Show simple item record Hitchcock, S.A. Meyer, Helgard Pieter Gwyther, E. 2009-03-16T09:30:46Z 2009-03-16T09:30:46Z 2008-11
dc.description.abstract Objective. To measure the prevalence, severity and morbidity of neuropathic pain in AIDS patients, prior to the initiation of antiretroviral (ARV) therapy.Design. A prospective, cross-sectional and descriptive-analytical study.Setting. The Kalafong Hospital HIV Clinic in Pretoria.Subjects. All patients with confirmed AIDS who were referred to the Kalafong HIV clinic to be initiated on ARV therapy during the period August 2006 to March 2007.Outcome measures. Data were collected regarding the presence and severity of neuropathic pain in each subject. Pain of predominantly neuropathic origin (POPNO) was identified using the Neuropathic Pain Diagnostic Questionnaire (DN4). Numerical rating scales (NRS), adapted from the Brief Pain Inventory, were used to measure pain severity and pain-related interference with six aspects of daily living.Results. Of the 354 patients studied, 20.9% (95% confidence interval (CI) 16.8 - 25.2%) had POPNO. This pain was significantly more frequent in patients who were male, had lower CD4+ counts or higher viral load levels, and those on TB treatment. Eighty per cent of patients with POPNO experienced significant pain (worst pain severity ≥ 5 out of 10 on a NRS). Pain-related interference was highest for enjoyment of life, mood and ability to work. There was a significant positive correlation between severity of pain and pain-related interference for all domains of daily living evaluated.Conclusions. POPNO results in significant suffering and impaired functioning in patients with AIDS. It is therefore imperative that clinicians assess patients with AIDS for the presence and severity of neuropathic pain and manage it, using the most recent evidence-based guidelines. en_US
dc.identifier.citation Hitchcock, SA, Meyer, HP & Gwyther, E 2008, 'Neuropathic pain in AIDS patients prior to antiretroviral therapy', South African Medical Journal, vol. 98, no. 11, pp. 889-892. [] en_US
dc.identifier.issn 0038-3469
dc.language.iso en en_US
dc.publisher Health and Medical Publishing Group en_US
dc.rights Health and Medical Publishing Group en_US
dc.subject Neuropathic pain en_US
dc.subject Acquired immune deficiency syndrome (AIDS) en_US
dc.subject Patients en_US
dc.subject Antiretroviral therapy (ART) en_US
dc.subject Morbidity en_US
dc.subject Prevalence en_US
dc.subject Severity en_US
dc.subject Prior therapy en_US
dc.subject Initiation en_US
dc.subject ARV therapy en_US
dc.subject Prospective study en_US
dc.subject Cross-sectional study en_US
dc.subject Descriptive-analytical study en_US
dc.subject Kalafong hospital en_US
dc.subject South Africa (SA) en_US
dc.subject Neuropathic Pain Diagnostic Questionnaire (DN4) en_US
dc.subject Numerical rating scales en_US
dc.subject Pain measurement en_US
dc.subject Daily living en_US
dc.subject POPNO en_US
dc.subject.lcsh AIDS (Disease) -- Patients
dc.subject.lcsh Nervous system -- Diseases
dc.subject.lcsh Antiretroviral agents
dc.title Neuropathic pain in AIDS patients prior to antiretroviral therapy en_US
dc.type Article en_US

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