Mental health, art adherence, and viral suppression among adolescents and adults living with HIV in South Africa : a cohort study

Show simple item record Haas, Andreas D. Lienhard, Raphael Didden, Christiane Cornell, Morna Folb, Naomi Boshomane, Tebatso M.G. Salazar‑Vizcaya, Luis Rufeux, Yann Nyakato, Patience Wettstein, Anja E. Tlali, Mpho Davies, Mary‑Ann Von Groote, Per Wainberg, Milton Egger, Matthias Maartens, Gary Joaska, John A. 2023-09-22T06:45:06Z 2023-09-22T06:45:06Z 2023-06
dc.description DATA AVAILABILITY: Data were obtained from the International epidemiology Databases to Evaluate AIDS–Southern Africa (IeDEA-SA). Data cannot be made available online because of legal and ethical restrictions. To request data, readers may contact IeDEA-SA for consideration by filling out the online form available at https://www.iedea-sa. org/contact-us/. en_US
dc.description.abstract We followed adolescents and adults living with HIV aged older than 15 years who enrolled in a South African private-sector HIV programme to examine adherence and viral non-suppression (viral load>400 copies/mL) of participants with (20,743, 38%) and without (33,635, 62%) mental health diagnoses. Mental health diagnoses were associated with unfavourable adherence patterns. The risk of viral non-suppression was higher among patients with organic mental disorders [adjusted risk ratio (aRR) 1.55, 95% confdence interval (CI) 1.22–1.96], substance use disorders (aRR 1.53, 95% CI 1.19–1.97), serious mental disorders (aRR 1.30, 95% CI 1.09–1.54), and depression (aRR 1.19, 95% CI 1.10–1.28) when compared with patients without mental health diagnoses. The risk of viral non-suppression was also higher among males, adolescents (15–19 years), and young adults (20–24 years). Our study highlights the need for psychosocial interventions to improve HIV treatment outcomes—particularly of adolescents and young adults—and supports strengthening mental health services in HIV treatment programmes. en_US
dc.description.department Nuclear Medicine en_US
dc.description.sponsorship University of Bern Research, the U.S. National Institutes of Health’s National Institute of Allergy and Infectious Diseases, the Eunice Kennedy Shriver National Institute of Child Health and Human Development, Division of Cancer Epidemiology and Genetics, National Cancer Institute, the National Institute of Mental Health, the National Institute on Drug Abuse, the National Heart, Lung, and Blood Institute, the National Institute on Alcohol Abuse and Alcoholism, the National Institute of Diabetes and Digestive and Kidney Diseases and the Fogarty International Center, Swiss National Science Foundation and the National Institutes of Health. en_US
dc.description.uri en_US
dc.identifier.citation Haas, A.D., Lienhard, R., Didden, C. et al. Mental Health, ART Adherence, and Viral Suppression Among Adolescents and Adults Living with HIV in South Africa: A Cohort Study. AIDS and Behavior 27, 1849–1861 (2023). en_US
dc.identifier.issn 1090-7165 (print)
dc.identifier.issn 1573-3254 (online)
dc.identifier.other 10.1007/s10461-022-03916-x
dc.language.iso en en_US
dc.publisher Springer en_US
dc.rights © The Author(s) 2022. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License. en_US
dc.subject Mental disorders en_US
dc.subject Adherence en_US
dc.subject Viral suppression en_US
dc.subject Human immunodeficiency virus (HIV) en_US
dc.subject Antiretroviral therapy (ART) en_US
dc.subject South Africa (SA) en_US
dc.subject SDG-03: Good health and well-being en_US
dc.subject People living with HIV (PLWHIV) en_US
dc.title Mental health, art adherence, and viral suppression among adolescents and adults living with HIV in South Africa : a cohort study en_US
dc.type Article en_US

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