Competing endogenous RNA (ceRNA) networks and splicing switches in cervical cancer : HPV oncogenesis, clinical significance and therapeutic opportunities

Show simple item record Basera, Afra Hull, Rodney Demetriou, Demetra Bates, David O. Kaufmann, Andreas Martin Dlamini, Zodwa Marima, Rahaba 2023-09-21T06:46:28Z 2023-09-21T06:46:28Z 2022-09-16
dc.description.abstract Cervical cancer (CC) is the primary cause of female cancer fatalities in low-middle-income countries (LMICs). Persistent infections from the human papillomavirus (HPV) can result in cervical cancer. However, numerous different factors influence the development and progression of cervical cancer. Transcriptomic knowledge of the mechanisms with which HPV causes cervical cancer pathogenesis is growing. Nonetheless, there is an existing gap hindering the development of therapeutic approaches and the improvement of patient outcomes. Alternative splicing allows for the production of numerous RNA transcripts and protein isoforms from a single gene, increasing the transcriptome and protein diversity in eukaryotes. Cancer cells exhibit astounding transcriptome modifications by expressing cancer-specific splicing isoforms. High-risk HPV uses cellular alternative splicing events to produce viral and host splice variants and proteins that drive cancer progression or contribute to distinct cancer hallmarks. Understanding how viruses utilize alternative splicing to drive pathogenesis and tumorigenesis is essential. Although research into the role of miRNAs in tumorigenesis is advancing, the function of other non-coding RNAs, including lncRNA and circRNA, has been understudied. Through their interaction with mRNA, non-coding RNAs form a network of competing endogenous RNAs (ceRNAs), which regulate gene expression and promote cervical cancer development and advancement. The dysregulated expression of non-coding RNAs is an understudied and tangled process that promotes cervical cancer development. This review will present the role of aberrant alternative splicing and immunosuppression events in HPV-mediated cervical tumorigenesis, and ceRNA network regulation in cervical cancer pathogenesis will also be discussed. Furthermore, the therapeutic potential of splicing disruptor drugs in cervical cancer will be deliberated. en_US
dc.description.department Medical Oncology en_US
dc.description.librarian am2023 en_US
dc.description.sponsorship We would like to thank the South African Medical Research Council (SAMRC), Grant Number 23108, and the National Research Foundation (NRF), Grant Number 138139, for funding this work. en_US
dc.description.sponsorship The South African Medical Research Council (SAMRC) and the National Research Foundation (NRF). en_US
dc.description.uri en_US
dc.identifier.citation Basera, A.; Hull, R.; Demetriou, D.; Bates, D.O.; Kaufmann, A.M.; Dlamini, Z.; Marima, R. Competing Endogenous RNA (ceRNA) Networks and Splicing Switches in Cervical Cancer: HPV Oncogenesis, Clinical Significance and Therapeutic Opportunities. Microorganisms 2022, 10, 1852. en_US
dc.identifier.issn 2076-2607 (online)
dc.identifier.other 10.3390/microorganisms10091852
dc.language.iso en en_US
dc.publisher MDPI en_US
dc.rights © 2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license. en_US
dc.subject Human papillomavirus (HPV) en_US
dc.subject Cervical cancer (CC) en_US
dc.subject Competing endogenous RNAs (ceRNAs) en_US
dc.subject Alternative splicing (AS) en_US
dc.subject Immunosuppression en_US
dc.subject Protein arginine methyltransferases (PMRTs) en_US
dc.subject Splicing disruptor drugs en_US
dc.subject Low- and middle-income countries (LMICs) en_US
dc.subject SDG-03: Good health and well-being en_US
dc.title Competing endogenous RNA (ceRNA) networks and splicing switches in cervical cancer : HPV oncogenesis, clinical significance and therapeutic opportunities en_US
dc.type Article en_US

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