Cardiovascular effects of intravenous vatinoxan in wild boars (Sus scrofa) anaesthetised with intramuscular medetomidine-tiletamine-zolazepam

Loading...
Thumbnail Image

Authors

Einwaller, Joy
Meyer, Leith Carl Rodney
Auer, Ulrike
Raekallio, Marja
Nowack, Julia
Haw, Anna
Vetter, Sebastian
Painer, Johanna
Stalder, Gabrielle

Journal Title

Journal ISSN

Volume Title

Publisher

Wiley

Abstract

BACKGROUND : The potent sedative medetomidine is a commonly used adjunct for the immobilisation of non-domestic mammals. However, its use is associated with pronounced cardiovascular side effects, such as bradycardia, vasoconstriction and decreased cardiac output. We investigated the effects of the peripherally-acting alpha-2-adrenoceptor antagonist vatinoxan on cardiovascular properties in medetomidine-tiletamine-zolazepam anaesthetised wild boar (Sus scrofa). METHODS : Twelve wild boars, anaesthetised twice with medetomidine (0.1 mg/kg) and tiletamine/zolazepam (2.5 mg/kg) IM in a randomised, crossover study, were administered (0.1 mg/kg) vatinoxan or an equivalent volume of saline IV (control). Cardiovascular variables, including heart rate (HR), mean arterial blood pressure (MAP), pulmonary artery pressure (PAP), pulmonary artery occlusion pressure (PAOP) and cardiac output (CO), were assessed 5 min prior to vatinoxan/saline administration until the end of anaesthesia 30 min later. RESULTS : MAP (p < 0.0001), MPAP (p < 0.001) and MPAOP (p < 0.0001) significantly decreased from baseline after vatinoxan until the end of anaesthesia. HR increased significantly (p < 0.0001) from baseline after vatinoxan administration. However, the effect on HR subsided 3 min after vatinoxan. All variables remained constant after saline injection. There was no significant effect of vatinoxan or saline on CO. CONCLUSION : Vatinoxan significantly reduced systemic and pulmonary artery hypertension, induced by medetomidine in wild boar.

Description

Keywords

Alpha-2-adrenergic agonists, Blood pressure, Medetomidine, Vatinoxan, Wild boar (Sus scrofa), Cardiac output, Pulmonary artery occlusion pressure (PAOP), Pulmonary artery pressure (PAP), Heart rate (HR), Mean arterial blood pressure (MAP)

Sustainable Development Goals

Citation

Einwaller, J., Meyer, L.C.R., Auer, U., Raekallio, M., Nowack, J., Haw, A., et al. Cardiovascular effects of intravenous vatinoxan in wild boars (Sus scrofa) anaesthetised with intramuscular medetomidine-tiletaminezolazepam. Veterinary Record 2021;e835. https://DOI.org/10.1002/vetr.835.