Review of the pig-adapted African swine fever viruses in and outside Africa

Show simple item record Penrith, Mary-Louise Van Heerden, Juanita Heath, Livio Abworo, Edward Okoth Bastos, Armanda 2022-12-14T12:30:40Z 2022-12-14T12:30:40Z 2022-10-16
dc.description.abstract The region in eastern, central and southern Africa (ECSA) where African swine fever (ASF) originated in a sylvatic cycle is home to all the p72 genotypes of ASF virus identified so far. While 20 of the 24 genotypes have been isolated from outbreaks in domestic pigs in the region, only five of the genotypes (I, II, VIII, IX, X) have an extended field presence associated with domestic pigs. Of the genotypes that appear to be strongly adapted to domestic pigs, two have spread beyond the African continent and have been the focus of efforts to develop vaccines against ASF. Most of the experimental ASF vaccines described do not protect against a wider spectrum of viruses and may be less useful in the event of incursions of different strains or where multiple genotypes co-exist. The other three pig-adapted strains that are currently restricted to the ECSA region might spread, and priority should be given to understanding not only the genetic and antigenic characteristics of these viruses but also their history. We review historic and current knowledge of the distribution of these five virus genotypes, and note that as was the case for genotype II, some pig-associated viruses have the propensity for geographical range expansion. These features are valuable for prioritizing vaccine-development efforts to ensure a swift response to virus escape. However, whilst ASF vaccines are critical for high-production systems, global food security relies on parallel efforts to improve biosecurity and pig production in Africa and on continued ASFV surveillance and characterisation in the ECSA region. en_US
dc.description.department Veterinary Tropical Diseases en_US
dc.description.department Zoology and Entomology en_US
dc.description.librarian dm2022 en_US
dc.description.sponsorship The Ecology and evolution of infectious diseases National Program. en_US
dc.description.uri en_US
dc.identifier.citation Penrith, M.-L.; Van Heerden, J.; Heath, L.; Abworo, E.O.; Bastos, A.D.S. Review of the Pig-Adapted African Swine Fever Viruses in and Outside Africa. Pathogens 2022, 11, 1190. en_US
dc.identifier.issn 2076-0817 (online)
dc.identifier.other 10.3390/pathogens11101190
dc.language.iso en en_US
dc.publisher MDPI en_US
dc.rights © 2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https:// 4.0/). en_US
dc.subject African swine fever en_US
dc.subject Genotypes en_US
dc.subject Pig-adapted en_US
dc.title Review of the pig-adapted African swine fever viruses in and outside Africa en_US
dc.type Article en_US

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